Fluorinated analogues as mechanistic probes in valproic acid hepatotoxicity: comparative metabolic and pharmacokinetic studies
A serious drawback in the use of the anticonvulsant agent valproic acid (VPA) is the drug associated liver toxicity characterized by microvesicular steatosis frequently accompanied by necrosis. The main objective of this thesis was to test the hypothesis that the hepatotoxicity of VPA is due to t...
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| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/2429/6204 |