Pro-apoptotic bax and bak control beta-cell death and early endoplasmic reticulum stress signalling
Functional failure and loss of pancreatic β-cells are critical events in the pathogenesis of diabetes and there is mounting evidence that suggests chronic endoplasmic reticulum (ER) stress contributes significantly to β-cell dysfunction and apoptotic death. Two core pro-apoptosis proteins, Bax and B...
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| Language: | English |
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University of British Columbia
2013
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| Online Access: | http://hdl.handle.net/2429/44609 |