Development of a hypoxia activated prodrug for the selective inhibition of DNA-dependent protein kinase
The presence of tumour hypoxia, regions of low levels of oxygen, is a distinct and exploitable feature of the solid tumour microenvironment. While its presence is generally accepted as a negative prognostic indicator, hypoxia is a relatively unique feature to solid tumours and can therefore be explo...
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| Language: | English |
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University of British Columbia
2013
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| Online Access: | http://hdl.handle.net/2429/44337 |