Overexpression of TDP-43 inhibits NF-κB activity by blocking p65 nuclear translocation

Overexpression of TDP-43 inhibits NF-κB activity by blocking p65 nuclear translocation

Show other versions (2)

TDP-43 (TAR DNA binding protein 43) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that has been found to be mainly responsible for neurodegenerative diseases recently. Its involvement in nuclear factor-kappaB pathways has been reported in neuron and microglial cells that are linked to amyo...

Full description

Bibliographic Details
Main Author:	Zhu , Jingyan
Language:	English
Published:	University of British Columbia 2013
Online Access:	http://hdl.handle.net/2429/44260

Similar Items

Overexpression of TDP-43 inhibits NF-κB activity by blocking p65 nuclear translocation
by: Zhu , Jingyan
Published: (2013)

Overexpression of TDP-43 inhibits NF-κB activity by blocking p65 nuclear translocation
by: Zhu , Jingyan
Published: (2013)

TDP-43 Inhibits NF-κB Activity by Blocking p65 Nuclear Translocation.
by: Jingyan Zhu, et al.
Published: (2015-01-01)

TDP-43 overexpression impairs presynaptic integrity
by: Lanier Heyburn, et al.
Published: (2016-01-01)

The impact of flow on the nuclear translocation of NF-κB
by: Baeriswyl, Daniel C.
Published: (2018)

Orientia tsutsugamushi uses two Ank effectors to modulate NF-κB p65 nuclear transport and inhibit NF-κB transcriptional activation.
by: Sean M Evans, et al.
Published: (2018-05-01)

PAK5-mediated phosphorylation and nuclear translocation of NF-κB-p65 promotes breast cancer cell proliferation in vitro and in vivo
by: Ying-Chun Zhang, et al.
Published: (2017-10-01)

RTA‐408 protects against propofol‐induced cognitive impairment in neonatal mice via the activation of Nrf2 and the inhibition of NF‐κB p65 nuclear translocation
by: Ling Zhang, et al.
Published: (2021-01-01)

Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage
by: Sai Sampath Thammisetty, et al.
Published: (2018-11-01)

SN50 attenuates alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome mice through inhibiting NF-κB p65 translocation
by: Yanqi Wu, et al.
Published: (2020-05-01)

Investigating the protein-protein interactions between TAR DNA-binding protein 43 AND p65 subunit of NF-κB
by: Lee, Joseph
Published: (2016)

p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death
by: A. D. Foster, et al.
Published: (2021-06-01)

TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
by: Lumi Zhang, et al.
Published: (2020-01-01)

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
by: Manami Deshimaru, et al.
Published: (2021-04-01)

The Expression of SOCS and NF-κB p65 in Hypopharyngeal Carcinoma
by: Shu FENG, et al.
Published: (2018-12-01)

Inhibition of TDP-43 aggregation by nucleic acid binding.
by: Yi-Chen Huang, et al.
Published: (2013-01-01)

Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons
by: Elaine Y. Liu, et al.
Published: (2019-04-01)

Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening.
by: Zi Di, et al.
Published: (2012-01-01)

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
by: Fernando Ormeño, et al.
Published: (2020-02-01)

Fumaric Acid Esters Do Not Reduce Inflammatory NF-κB/p65 Nuclear Translocation, ICAM-1 Expression and T-Cell Adhesiveness of Human Brain Microvascular Endothelial Cells
by: Axel Haarmann, et al.
Published: (2015-08-01)

Regulation of nuclear factor κB (NF-κB) transcriptional activity via p65 acetylation by the chaperonin containing TCP1 (CCT).
by: Nadja Pejanovic, et al.
Published: (2012-01-01)

Conditioned Medium from Cells Overexpressing TDP-43 Alters the Metabolome of Recipient Cells
by: Rudolf Hergesheimer, et al.
Published: (2020-09-01)

Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.
by: Sei-Kyoung Park, et al.
Published: (2017-05-01)

Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis
by: Matthew D. Cykowski, et al.
Published: (2018-04-01)

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.
by: Hayley J Newton, et al.
Published: (2010-05-01)

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.
by: Sarah J Parker, et al.
Published: (2012-01-01)

Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization
by: Emile S. Pinarbasi, et al.
Published: (2018-05-01)

TDP-43: From Alzheimer’s Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy
by: Wendi Huang, et al.
Published: (2020-02-01)

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
by: Rachel Atkinson, et al.
Published: (2021-02-01)

Development of novel peptides for blocking aggregation and caspase-3 cleavage of TDP-43
by: Liu, Rui
Published: (2011)

Development of novel peptides for blocking aggregation and caspase-3 cleavage of TDP-43
by: Liu, Rui
Published: (2011)

Development of novel peptides for blocking aggregation and caspase-3 cleavage of TDP-43
by: Liu, Rui
Published: (2011)

The rate of NF-κB nuclear translocation is regulated by PKA and A kinase interacting protein 1.
by: Charles C King, et al.
Published: (2011-04-01)

Modulation of LPS-induced ROS production and NF-κB nuclear translocation by N-stearoylethanolamine in macrophages
by: A. G. Berdyshev, et al.
Published: (2017-10-01)

The pathological phenotypes of human TDP-43 transgenic mouse models are independent of downregulation of mouse Tdp-43.
by: Ya-Fei Xu, et al.
Published: (2013-01-01)

TDP-43 and Phosphorylated TDP-43 Levels in Paired Plasma and CSF Samples in Amyotrophic Lateral Sclerosis
by: Yuting Ren, et al.
Published: (2021-06-01)

The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response
by: Shinrye Lee, et al.
Published: (2020-10-01)

Inhibition of TDP-43 Aggregation using Native State Binding Ligands
by: Sun, Yulong
Published: (2014)

Inhibition of TDP-43 Aggregation using Native State Binding Ligands
by: Sun, Yulong
Published: (2014)

Combined use of CSF NfL and CSF TDP‐43 improves diagnostic performance in ALS
by: Takashi Kasai, et al.
Published: (2019-12-01)