Effect of cimetidine on hepatic cytochromes P450 1A and P450 2C in male rats
Cimetidine, an H₂-antagonist, is an inhibitor of hepatic cytochromes P450 in humans and male rats, both in vivo and in vitro. Results of early in vitro studies with rat hepatic microsomes showed that cimetidine, at concentrations in the millimolar range, inhibits many cytochrome P450-mediated enzy...
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| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/2429/3993 |