The effect of hypoxia on cytotoxicity, uptake and DNA binding of cisplatin and novel bis(platinum) complexes in Chinese hamster ovary cells
Disagreement exists in the literature as to whether the successful antitumour agent cisplatin exhibits greater toxicity in hypoxia than in air. In this study, Chinese hamster ovary cells were incubated in clinically relevant concentrations of cisplatin for periods of up to three hours in aerobic and...
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| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/2429/3371 |