Improving DNAzyme catalysis through synthetically modified DNAzymes and probing DNA polymerase function to improve selection methodology
DNA enzymes (DNAzymes) are part of a growing field of nucleic acid-based catalysts. Unlike ribozymes, DNAzymes have no apparent precedence in nature to date and can only be discovered through in vitro selection. These selections can accommodate both natural and chemically-functionalized nucleotide...
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| Language: | English |
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University of British Columbia
2011
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| Online Access: | http://hdl.handle.net/2429/30659 |