Mechanistic studies of natural ribozymes and a synthetic DNAzyme
This thesis reports the results of experiments designed to help elucidate the catalytic mechanisms of three RNA cleaving nucleic acid catalysts (the 9₂₅-11 DNAzyme, and the hammerhead and hairpin ribozymes). A number of enzymological and chemical probing experiments were employed in this regard, wh...
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| Language: | English |
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University of British Columbia
2009
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| Online Access: | http://hdl.handle.net/2429/12563 |