Drug resistance in breast cancer : effect of Bcl-2 level on the responsiveness of two mammary carcinoma cell lines to chemotherapeutic agents

The Bcl-2 pro-survival protein is an important regulator of apoptosis and has been implicated in mechanisms of drug resistance by virtue of the expression levels of this protein in the cell. In these studies we sought to determine the effect of the inherent Bcl-2 level in breast cancer cell lines...

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Bibliographic Details
Main Author: Sartor, Jason Robert
Language:English
Published: 2009
Online Access:http://hdl.handle.net/2429/12215