| Summary: | We assessed the ability of contextual conditional stimuli that are normally present during
the course of kindling to modulate both motor seizures and interictal behavior. Rats received 53
stimulations to the left basolateral amygdala in one context (CS+) and 53 sham stimulations (The
lead was attached but no current was delivered.) in another context (CS-), quasirandomly over 54
days. We observed 3 kinds of conditional effects. First, after several stimulations, less
ambulatory activity, more freezing, and less rearing reliably occurred in the CS+ context than in
the CS- context. Second, after 45 stimulations, all of the rats chose the CS- context over the CS+
context in a conditioned place-preference test. Third, when the rats were finally stimulated in the
CS- context, their motor seizures were less severe in several respects: Latencies were longer,
motor seizures were shorter, convulsive patterns were of a lower class, and there were fewer
falls.
|
|---|
