Development of oxidative methodologies and application toward tetrodotoxin core
This thesis covers a novel approach to tetrodotoxin that relies on the oxidative amidation of a phenol and intramolecular nitrile oxide cycloaddition to install a β-hydroxynitrile unit among the key steps. These transformations, and others contained herein, effectively set the tetrasubstituted C-8a...
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| Language: | English |
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University of British Columbia
2010
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| Online Access: | http://hdl.handle.net/2429/30362 |