Instrumentation for Interstitial Photodynamic Therapy of Prostatic Carcinoma

Instrumentation for Interstitial Photodynamic Therapy of Prostatic Carcinoma

This thesis encompasses the development and testing of an interstitial photodynamic therapy (iPDT) system for the treatment of prostate cancer. It begins with the optical characterization of a novel photosensitizer (SL-052) followed by a study of tissue optics as it applies to iPDT. The design and i...

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Bibliographic Details
Main Author: Liu, Weiyang
Other Authors: Tulip, John (Electrical and Computer Engineering)
Format: Others
Language:en
Published: 2010
Subjects:
Photodynamic Therapy
Porstate Cancer
Interstitial
SL-052
Intra-Arterial
Fractionated Light Delivery
Pulsed Delivery
Switched Delivery
Real-Time Monitoring
Spectral Detection
Oscillations
Dosimetry
Hypocrellin
PDT
Online Access:http://hdl.handle.net/10048/942
Description
Summary:This thesis encompasses the development and testing of an interstitial photodynamic therapy (iPDT) system for the treatment of prostate cancer. It begins with the optical characterization of a novel photosensitizer (SL-052) followed by a study of tissue optics as it applies to iPDT. The design and integration of a time-fractionated light delivery system with real-time spectral detection is then examined. An optical phantom test medium is formulated and in vitro system operation and testing is performed. Finally, in vivo experiments are performed on animal models with a focus on canine prostate iPDT. Unique optical results with dosimetric relevance are discovered and investigated. This includes metrics for optically measuring local in vivo SL-052 concentrations in real-time as well as novel oscillatory drug photobleaching and recovery behavior during time-fractionated light delivery. === Photonics and Plasmas

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