Sustained acidosis and phenylephrine activate the myocardial Na+/H+ exchanger through phosphorylation of Ser770 and Ser771

Sustained acidosis and phenylephrine activate the myocardial Na+/H+ exchanger through phosphorylation of Ser770 and Ser771

The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitously expressed membrane protein that regulates myocardial intracellular pH. Inhibition of NHE1 prevents hypertrophy and reduces ischemia-reperfusion (I/R) injury in animal models. To understand the regulation of NHE1 in the myocardium by p...

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Bibliographic Details
Main Author: Coccaro, Ersilia
Other Authors: Fliegel, Larry (Biochemistry)
Format: Others
Language:en
Published: 2009
Subjects:
sodium hydrogen exchanger
sustained acidosis
phenylephrine
myocardium
extracellular regulated kinase 1/2
p90 risobomal S6 kinase
Online Access:http://hdl.handle.net/10048/845

Internet

http://hdl.handle.net/10048/845

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