Citochromų P450 katalizuojamo vaistų metabolizmo kompiuterinis modeliavimas

Citochromų P450 katalizuojamo vaistų metabolizmo kompiuterinis modeliavimas

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Pagrindinis šio darbo tikslas buvo kiekybinio struktūros ir aktyvumo ryšio modelių, prognozuojančių su vaistų metabolizmu susijusias savybes, kūrimas. Modeliai, prognozuojantys CYP3A4 slopinimą ir žmogaus kepenų mikrosomų katalizuojamo metabolizmo regioselektyvumą, buvo sukurti naudojant GALAS (angl...

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Bibliographic Details
Main Author:	Dapkūnas, Justas
Other Authors:	Kirvelienė, Vida
Format:	Doctoral Thesis
Language:	Lithuanian
Published:	Lithuanian Academic Libraries Network (LABT) 2011
Subjects:	Biochemistry Citochromai P450 QSAR CYP3A4 slopinimas Vaistų metabolizmas Regioselektyvumo progozavimas Cytochrome P450 CYP3A4 inhibition Drug metabolism Regioselectivity prediction
Online Access:	http://vddb.laba.lt/fedora/get/LT-eLABa-0001:E.02~2011~D_20111003_114342-83717/DS.005.0.01.ETD

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