A directed evolution design of target specificity and kinetic analysis of conformational transitions in the HhaI methyltransferase

A directed evolution design of target specificity and kinetic analysis of conformational transitions in the HhaI methyltransferase

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DNA cytosine-5 methyltransferases (MTases) recognize short DNA sequences and catalyze the transfer of the methyl group from the cofactor AdoMet to the C5-position of a target cytosine. In this work both these aspects of the MTase mechanism have been addressed. First, using rational protein design an...

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Bibliographic Details
Main Author: Gerasimaitė, Rūta
Other Authors: Mildažienė, Vida
Format: Doctoral Thesis
Language:English
Published: Lithuanian Academic Libraries Network (LABT) 2011
Subjects:
Biochemistry
DNA methyltransferase
Specificity
Base flipping
DNR metiltransferazės
Specifiškumas
Bazės išsukimas
Online Access:http://vddb.laba.lt/fedora/get/LT-eLABa-0001:E.02~2011~D_20110519_082240-87105/DS.005.1.01.ETD

Internet

http://vddb.laba.lt/fedora/get/LT-eLABa-0001:E.02~2011~D_20110519_082240-87105/DS.005.1.01.ETD

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