Hipertoninio hidroksietilkrakmolo tirpalo įtaka hemodinamikai, kvėpavimui ir homeostazei koreguojant hipovolemiją ligoniams po širdies operacijų

• Main Author: Šneider, Edvin
• Other Authors: Skurvydas, Albertas
• Format: Doctoral Thesis
• Language: Lithuanian
• Published: Lithuanian Academic Libraries Network (LABT) 2005
• Subjects: Medicine; Small-volume resuscitation; Heart surgery; Hypovolemia; Hypertonic solutions
• Online Access: http://vddb.library.lt/fedora/get/LT-eLABa-0001:E.02~2005~D_20050923_130237-24808/DS.005.0.02.ETD

Conclusions 1. In comparison to the Ringer‘s acetate solution the use of HyperHaes® solution after coronary artery bypass surgery had positive effect on haemodynamic parameters: cardiac index increased (p<0.05), systolic volume index increased (p<0.05), cardiac afterload decreased, that is pulmonary vascular resistance index decreased (p<0.05) and systemic vascular resistance index decreased (p<0.05); the difference between the central and peripheral temperatures in experimental group (p<0.05). 2. The oxygen transport was more effective (oxygen delivery index increased (p<0.05)) when HyperHaes® solution was used in comparison to Ringer‘s acetate solution. 3. No substantial effect of HyperHaes® solution on the duration of artificial lung ventilation and intrapulmonary shunt size was defined. 4. The use of HyperHaes® solution influenced substantially some parameters of homeostasis (serum sodium concentration increased (p<0.05), serum potassium concentration decreased (p<0.05)) in compa-rison to Ringer‘s acetate solution. 5. Higher diuresis (p<0.01), lower need for the infusion therapy for the first 24 hours (p<0.05), lower total fluid balance (p<0.01) were determined in HyperHaes® group versus Ringer‘s acetate group. 6. No adverse effects (disturbances of homeostasis, neurologic symptoms, increased bleeding through mediastinal tubes, anaphylactic reactions) were noted in patients who received HyperHaes® solution.