Mechanisms and quantitative prediction of Efavirenz metabolism, pharmacogenetics and drug interactions

Mechanisms and quantitative prediction of Efavirenz metabolism, pharmacogenetics and drug interactions

Indiana University-Purdue University Indianapolis (IUPUI) === The antiretroviral drug efavirenz remains a cornerstone for treatment-naïve HIV patients. Subsequent to the demonstration that efavirenz is a substrate of cytochrome P450 (CYP) 2B6, a number of clinical studies found that the CYP2B6*6 all...

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Bibliographic Details
Main Author: Xu, Cong
Other Authors: Desta, Zeruesenay
Language:en_US
Published: 2014
Subjects:
Drug Metabolism
Efavirenz
Pharmacokinetics
HIV infections > Chemotherapy > Research
HIV infections > Treatment
Antiretroviral agents > Research > Evaluation
Pharmacokinetics > Research
Drugs > Metabolism
Cytochrome P-450 > Analysis
HIV (Viruses) > Enzymes
Reverse transcriptase > Inhibitors > Therapeutic use
Drug interactions
Online Access:http://hdl.handle.net/1805/4212

Internet

http://hdl.handle.net/1805/4212

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