\"Caracterização molecular de mutações no gene pncA de isolados clínicos de Mycobacterium tuberculosis de origem brasileira\"
A Pirazinamida (Z), droga de primeira linha usada no tratamento da tuberculose, necessita ser hidrolisada pela enzima bacteriana pirazinamidase (PZase) para que o seu metabólito ativo, o ácido pirazinóico (POA), possa agir. O principal mecanismo molecular de resistência a esta droga envolve muta...
Main Author: | Patricia Barco |
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Other Authors: | Mario Hiroyuki Hirata |
Language: | Portuguese |
Published: |
Universidade de São Paulo
2004
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Subjects: | |
Online Access: | http://www.teses.usp.br/teses/disponiveis/9/9136/tde-15082006-201342/ |
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