Celecoxibe versus ibuprofeno no controle da sintomatologia p?s-operat?ria em exodontias de terceiros molares : estudo cl?nico randomizado duplo-cego

• Main Author: Barreiro, Bernardo Ottoni Braga
• Other Authors: Cherubini, Karen
• Format: Others
• Language: Portuguese
• Published: Pontif?cia Universidade Cat?lica do Rio Grande do Sul 2018
• Subjects: Terceiro Molar; Celecoxibe; Ibuprofeno; Dor; Qualidade de Vida; CIENCIAS DA SAUDE::ODONTOLOGIA
• Online Access: http://tede2.pucrs.br/tede2/handle/tede/8184

Submitted by PPG Odontologia ([e-mail]) on 2018-06-01T17:12:31Z No. of bitstreams: 1 BERNARDO_OTTONI_BRAGA_BARREIRO_DIS.pdf: 1279870 bytes, checksum: affbbc980239fa99dc3b0b7d225c5d1f (MD5) === Rejected by Caroline Xavier ([e-mail]), reason: Devolvido devido ? falta de capa institucional no arquivo PDF. on 2018-06-11T20:43:38Z (GMT) === Submitted by PPG Odontologia ([e-mail]) on 2018-06-26T18:17:12Z No. of bitstreams: 1 BERNARDO_OTTONI_BRAGA_BARREIRO_DIS.pdf: 1564508 bytes, checksum: eb25d8cf7206b34f1147dd7f78ef86c3 (MD5) === Approved for entry into archive by Sheila Dias ([e-mail]) on 2018-07-03T11:15:53Z (GMT) No. of bitstreams: 1 BERNARDO_OTTONI_BRAGA_BARREIRO_DIS.pdf: 1564508 bytes, checksum: eb25d8cf7206b34f1147dd7f78ef86c3 (MD5) === Made available in DSpace on 2018-07-03T11:21:51Z (GMT). No. of bitstreams: 1 BERNARDO_OTTONI_BRAGA_BARREIRO_DIS.pdf: 1564508 bytes, checksum: eb25d8cf7206b34f1147dd7f78ef86c3 (MD5) Previous issue date: 2018-01-24 === Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES === Third molar extraction is a surgical procedure with significant morbidity in the postoperative period. The aim of the present study was to compare postoperative effects of celecoxib (200 mg/day) and ibuprofen (1,800 mg/day) on trismus, swelling, pain and quality of life of patients subjected to extraction of third molars. A randomized double-blind clinical trial was conducted. Fifteen patients were submitted to extraction of impacted third molars, right and left, at different times. Oral dexamethasone (8 mg) was given preoperatively and for postoperative analgesia, celecoxib was administered for one side tooth extraction and ibuprofen for the other. Pain, swelling, trismus and quality of life were scored with a visual analogical scale (VAS), facial linear measurements and Oral Health Impact Profile questionnaire (OHIP-14). Trismus did not significantly differ between the groups. Angle of the mandible to the nasal border distance was significantly lower in the ibuprofen group at 0.5 h and 48 h. OHIP-14 total score was significantly lower in the ibuprofen group at 48 h, where differences occurred for functional limitation, physical pain and physical disability domains. No significant differences occurred at the other OHIP-14 times and domains. Pain VAS was significantly lower in the ibuprofen group at 4, 8, 24, 48 and 72 h. Swelling VAS was significantly lower in the ibuprofen group at 2, 6, 12, 72 and 96 h. Rescue medication was more often in the celecoxib group, but without significant difference considering the number of tablets used. Frequency of infection and duration of surgical procedure did not significantly differ between the groups. === A extra??o de terceiros molares constitui procedimento cir?rgico frequente e de significativa morbidade durante o per?odo p?s-operat?rio. O presente estudo teve por objetivo comparar o efeito p?s-operat?rio dos f?rmacos celecoxibe (200 mg/dia) e ibuprofeno (1.800 mg/dia) sobre os par?metros trismo, edema, dor e qualidade de vida em paciente submetidos a exodontias de terceiros molares. Um estudo cl?nico randomizado duplo-cego foi conduzido, em que 15 pacientes foram submetidos a exodontias de terceiros molares, dos lados direito e esquerdo, em diferentes momentos. Os pacientes receberam 8 mg de dexametasoan por via oral no pr?-oprat?rio e, para analgesia p?s-operat?ria, celecoxibe foi administrado para um lado das extra??es e ibuprofeno foi administrado para o outro. Dor, edema, trismo e qualidade de vida foram avaliados por meio de escala analogica visual (VAS), medidas faciais lineares e pelo invent?rio Oral Health Impact Profile (OHIP-14). O trismo n?o diferiu significativamente entre os grupos. A dist?ncia ?ngulo da mand?bula-asa do nariz (Go-Al) foi significativamente menor para o grupo ibuprofeno nos per?odos de 0.5 h e 48 h. O escore total do OHIP-14 foi significativamente menor no grupo ibuprofeno no per?odo de 48 h, sendo verificadas diferen?as significativas para os dom?nios limita??o funcional, dor f?sica, e incapacidade f?sica. N?o ocorreram diferen?as significativas para os demais per?odos e dom?nios do OHIP-14. A VAS de dor foi significativamente menor no grupo ibuprofeno nos per?odos 4, 8, 24, 48 e 72 h. A VAS de edema foi significativamente menor no grupo ibuprofeno nos per?odos 2, 6, 12, 72 e 96 h. A frequ?ncia de uso da terapia analg?sica de resgate foi maior no grupo celecoxibe, mas sem diferen?a significativa para o n?mero de comprimidos usados. A frequ?ncia de infec??o e a dura??o da cirurgia n?o diferiram significativamente entre os grupos.