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Previous issue date: 2015-01-27 === Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES === This Master?s research is composed of two empirical papers, the first one is a
characterization of quality of life (QoL), physical and psychosocial factors in patients with
Colorectal cancer (CRC). The second reference is to the identification of factors that can
predict QoL in this population. The objectives that guided this thesis were to characterize
patients with this cancer and to identify factors that predict QoL in patients with CRC . As a
method carried out a longitudinal evaluation at baseline and at follow -up 51 patients elected
for convenience and were assessed through self-report to QoL in addition to social
demographic and clinical variables. On the other hand, if sought - diagnostic and therapeutic
information in the medical records. After, there was descriptive and inferential statistics
analysis establishing the necessary comparisons and correlations. The results identified a
characteristic profile with relatively homogeneous distribution 51 % men with the middle age
of 60.1 ( ?9,1) at baseline , as psychosocial aspects in general had higher QoL with other
studies on the same population , and a significant improvement over time of all the subscales
of performance and symptoms. Also shown that the physical aspects influence QoL.
Concerning the predictors in this study there was no evidence links between gender and QoL,
except for the initial assessment during chemotherapy indicating relationship between a man
predicts to have more diarrhea. Another relevant fact is the relationship schooling, which have
higher level indicates greater loss in appetite seconds findings at baseline. The presence of
pain at follow -up can be correlated with the fact living alone. When considering the treatment
protocols, FOLFIRI and Bevacizumab shown to be related to worse QoL. Also, if the trend
showed a pain as a predictor of poor QoL. The relationship between self QoL l reporting
among individuals who died and the survivors had minimum ratio indicating that they are
independent. Regarding the presence of the mutated K-RAS gene the unique relationship was
related with appetite loss. Finally, the symptoms of anxiety and depression were important
predictors global QoL subscales and at follow-up. The main conclusion of the study findings
is the need for multidisciplinary care that addresses the specific demands on this diagnosis. === Esta disserta??o est? constitu?da de dois estudos emp?ricos, o primeiro trata-se de uma
caracteriza??o de qualidade de vida (QV), fatores f?sicos e psicossociais em pacientes com
C?ncer de col?n e reto (CCR). J? o segundo trata-se da identifica??o de fatores que podem
predizer QV nesta popula??o. Os objetivos que nortearam esta disserta??o foram de
caracterizar os portadores desta neoplasia e identificar fatores que est?o associados ? QV em
pacientes com CCR. Como m?todo realizou-se uma avalia??o longitudinal na linha de base e
no follow-up com 51 pacientes eleitos por conveni?ncia, sendo avaliados atrav?s de
autorrelato para QV al?m de vari?veis s?cio demogr?ficas e cl?nicas. Por outro lado,
buscaram-se informa??es diagn?sticas e terap?uticas nos prontu?rios m?dicos. Ap?s, realizouse
an?lises estat?sticas descritivas e inferenciais estabelecendo as devidas compara??es e
correla??es. Os resultados identificaram um perfil caracter?stico com distribui??o
relativamente homog?nea 51% s?o homens com idade m?dia de 60,1 (?9,1) na linha de base,
como aspectos psicossociais em geral apresentaram QV superior a outros estudos com a
mesma popula??o, al?m de uma melhora significativa com o passar do tempo de todas as
subescalas de desempenho e sintomas. Tamb?m evidenciado que os aspectos f?sicos
influenciam na QV. Concernente aos fatores preditores, neste estudo, n?o se evidenciou
rela??es entre sexo e QV, a exce??o da avalia??o inicial durante a quimioterapia que indica
rela??o entre ser homem e ter mais diarreia. Outro dado relevante ? em rela??o ? escolaridade,
onde ter n?vel superior indica maior preju?zo no apetite segundo achados na linha de base. A
presen?a de dor no follow-up pode ser correlacionada com o fato de morar sozinho. Quando
considerados os protocolos de tratamento, Folfiri + Bevacizumbe demonstraram estar
relacionados ? pior QV. Al?m disso, se evidenciou uma tend?ncia da dor como preditora de
pobre QV. A rela??o entre auto relato de QV entre os indiv?duos que foram a ?bito e os
sobreviventes apresentaram rela??o m?nima indicando que s?o independentes. No que diz
respeito da presen?a do gene K-RAS a ?nica rela??o foi este estar relacionado ? perda de
apetite. Por fim, os sintomas de ansiedade e depressivos demonstraram ser importantes fatores
associados ? QV global e subescalas no follow-up. Como principal conclus?o dos achados
deste estudo est? ? necessidade de cuidado multiprofissional que contemple demandas
especificas a este diagn?stico.
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