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Previous issue date: 2012-08-28 === The aim of this study was to check if there is a predictive relationship of measured serum levels of anti-Mullerian hormone (AMH), antral follicle count (AFC) and ovarian volume with the results of IVF. We conducted a prospective study between January 2010 and March 2012 with women aged 35 or more who underwent IVF. The levels of AMH, AFC and ovarian volume were correlated with response to ovarian hyperstimulation, with rates of fertilization, with embryo quality and pregnancy rates. We evaluated 40 patients with a median age of 39 years old. There was a significant direct correlation between the levels of AMH and the number of follicles larger than 14 mm (rS = 0.81 and P < 0.001). The same happened to the AFC (rS = 0.69 and P < 0.001). This correlation was not significant when evaluated the ovarian volume. AMH, AFC and ovarian volume did not show a statistically significant correlation with rates of fertilization, with embryo quality or with pregnancy rates. In predicting good or poor response, AMH and AFC showed a high positive predictive value (100% for the AMH and 87% for AFC, using a cutoff of 0.9 ng/ml and 7 follicles respectively, values established by ROC curve). We conclude from this study that AMH and AFC can be used as predictors of response to ovarian hyperstimulation in IVF, but they are not related to embryo quality, fertilization rates or pregnancy. === O objetivo deste estudo foi verificar se existe rela??o preditiva da medida do n?vel s?rico do horm?nio antim?lleriano (HAM), da contagem de fol?culos antrais (CFA) e do volume ovariano com os resultados de FIV. Realizou-se um estudo prospectivo no per?odo de janeiro de 2010 a mar?o de 2012 com mulheres de 35 anos ou mais que realizaram FIV. Os n?veis do HAM, CFA e volume ovariano foram correlacionados com resposta ? hiperestimula??o ovariana, com as taxas de fertiliza??o, com a qualidade dos embri?es e com os ?ndices de gesta??o. Foram avaliadas 40 pacientes com uma mediana de idade de 39 anos. Observou-se uma correla??o direta significativa entre os n?veis do HAM e o n?mero de fol?culos maiores de 14 mm (rS = 0,81 e P < 0,001), ocorrendo o mesmo com a CFA (rS = 0,69 e P < 0,001). Tal correla??o n?o foi significativa quando avaliado o volume ovariano. HAM, CFA e volume ovariano n?o apresentaram uma correla??o estatisticamente significativa com as taxas de fertiliza??o, com a qualidade embrion?ria, nem com os ?ndices gesta??o. Na predi??o de boa ou m? resposta, HAM e CFA apresentaram um alto valor preditivo positivo (100% para o HAM e 87% para a CFA, usando um ponto de corte de 0,9 ng/ml e 7 fol?culos respectivamente, valores estabelecidos pela curva ROC). Conclu?mos, com o estudo, que HAM e CFA podem ser utilizados como preditores da resposta ? hiperestimula??o ovariana em FIV; por?m, n?o est?o relacionados ? qualidade embrion?ria, taxas de fertiliza??o ou gesta??o.
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