Influ?ncia dos odores de gato e de cobra no comportamento defensivo e express?o de fos do sistema hipotal?mico de defesa de camundongo

• Main Author: Oliveira, Karen Crisanto de
• Other Authors: 02588073425
• Language: Portuguese
• Published: Universidade Federal do Rio Grande do Norte 2016
• Subjects: CNPQ::CIENCIAS BIOLOGICAS: PSICOBIOLOGIA; Camundongo; Est?mulos odor?feros; Sistema Hipotal?mico de Defesa; Fos; Comportamento defensivo
• Online Access: http://repositorio.ufrn.br/handle/123456789/20308

Submitted by Automa??o e Estat?stica ([e-mail]) on 2016-04-25T23:08:58Z No. of bitstreams: 1 KarenCrisantoDeOliveira_DISSERT.pdf: 1361957 bytes, checksum: b209b79db41ee94dbb8c96a8da57599b (MD5) === Approved for entry into archive by Arlan Eloi Leite Silva ([e-mail]) on 2016-04-27T23:45:33Z (GMT) No. of bitstreams: 1 KarenCrisantoDeOliveira_DISSERT.pdf: 1361957 bytes, checksum: b209b79db41ee94dbb8c96a8da57599b (MD5) === Made available in DSpace on 2016-04-27T23:45:33Z (GMT). No. of bitstreams: 1 KarenCrisantoDeOliveira_DISSERT.pdf: 1361957 bytes, checksum: b209b79db41ee94dbb8c96a8da57599b (MD5) Previous issue date: 2015-05-08 === Estudos com tra?ador neuronal em rato tem demonstrado que os n?cleos anterior do hipot?lamo, divis?o dorsomedial do n?cleo ventromedial do hipot?lamo e pr?-mamilar dorsal s?o altamente conectados. Quando o rato ? exposto ao predador ou seu odor estes n?cleos apresentam alta express?o de Fos e a les?o deles reduz o comportamento defensivo contra predador. A este conjunto de n?cleos foi dado o nome de Sistema Hipotal?mico de Defesa. No entanto, pouco se sabe sobre a resposta deste sistema ao odor de diferentes predadores ou seu papel em camundongos. Neste trabalho, expusemos camundongos Swiss aos odores de dois predadores (gato e cobra) para verificar a express?o de Fos no Sistema Hipotal?mico de Defesa, assim como os comportamentos defensivos exibidos. A an?lise mostrou que a exposi??o do camundongo ao odor de gato provocou um aumento na express?o da prote?na Fos comparado ao controle, enquanto que o odor de cobra n?o teve o mesmo efeito, o que foi corroborado pelos dados comportamentais. Nossos resultados indicam que esse distinto circuito em camundongo parece agir diferencialmente aos est?mulos odor?feros de diferentes predadores, provocando rea??es comportamentais distintas, sendo que o odor de cobra parece n?o ser percebido como um est?mulo amea?ador pelos camundongos Swiss. === Studies using neuronal tract-tracer in rat have shown that the anterior hypothalamic nucleus, dorsomedial division of the ventromedial nucleus of the hypothalamus and dorsal premammillary nucleus are highly connected. When the rat is exposed to predator or its odor these nuclei have shown a expression of Fos and their lesion reduces defensive behavior against predator. This set of nuclei was named the Hypothalamic Defense System. However, little is known about the response of this system to the odor of different predators or its role in mice. In this work, we exposed Swiss mice to two different predators odor (cat and snake) to verify the Fos expression in the Hypothalamic Defense System, as well as the defensive behaviors displayed. The analysis showed that the mice exposure to cat odor had an increased expression of Fos protein compared to control, while those exposed to snake odor showed no rise in Fos expression, which was corroborated by the behavioral data. Our results indicate that this distinct circuit in mice seems to act differentially to odorous stimuli of different predators, causing distinct behavioral responses of mice and that the odor of snake seems not to be perceived by Swiss mice as a threatening stimulus.