Epidemiologia e caracteriza??o molecular dos v?rus Dengue circulantes no Rio Grande do Norte, 2013-2014

• Main Author: Carvalho, Daise Maria Cunha de Sousa
• Other Authors: 01016476469
• Language: Portuguese
• Published: Universidade Federal do Rio Grande do Norte 2016
• Subjects: CNPQ::CIENCIAS BIOLOGICAS; V?rus Dengue; Epidemiologia; Rio Grande do Norte
• Online Access: http://repositorio.ufrn.br/handle/123456789/19860

Submitted by Automa??o e Estat?stica ([e-mail]) on 2016-02-22T23:19:51Z No. of bitstreams: 1 DaiseMariaCunhaDeSousaCarvalho_DISSERT.pdf: 1677103 bytes, checksum: 02762c1d44bfc8363c0e7f941c0a3284 (MD5) === Approved for entry into archive by Arlan Eloi Leite Silva ([e-mail]) on 2016-02-26T00:20:08Z (GMT) No. of bitstreams: 1 DaiseMariaCunhaDeSousaCarvalho_DISSERT.pdf: 1677103 bytes, checksum: 02762c1d44bfc8363c0e7f941c0a3284 (MD5) === Made available in DSpace on 2016-02-26T00:20:08Z (GMT). No. of bitstreams: 1 DaiseMariaCunhaDeSousaCarvalho_DISSERT.pdf: 1677103 bytes, checksum: 02762c1d44bfc8363c0e7f941c0a3284 (MD5) Previous issue date: 2015-03-31 === Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq === A dengue ? uma doen?a infecciosa aguda, geralmente transmitida por mosquitos Aedes aegypti. O agente etiol?gico pertence ? fam?lia Flaviviridae, g?nero Flavivirus e compreende quatro sorotipos antigenicamente relacionados, por?m distintos: DENV-1, 2, 3 e 4. No Brasil, a doen?a representa um problema de sa?de p?blica nacional. O objetivo do presente estudo foi descrever os aspectos epidemiol?gicos da dengue no Estado do Rio Grande do Norte, no per?odo de 2013 a 2014. Um total de 483 amostras de sangue ou soro, no per?odo de Janeiro de 2013 a Dezembro de 2014, foi estudado pela metodologia de RT-PCR para a detec??o e tipagem viral. A infec??o foi confirmada em 36,44% (176/483) dos casos estudados. Este estudo detectou a circula??o de tr?s sorotipos do v?rus da dengue no Rio Grande do Norte, DENV-1, 2 e 4. O sorotipo predominante em 2013-2014 foi o DENV-4, representando 83,51% (81/97) e 68,35% (54/79) dos casos positivos, respectivamente. Em rela??o ? distribui??o espacial, a maioria dos casos ocorreu em Natal e Caic?, com 9,28% (9/97) e 18,99% (15/79), respectivamente. Os meses com maior circula??o viral no RN foram Mar?o, em 2013 e Maio, em 2014. O sexo feminino foi o mais acometido, representando 69,07% (67/97) em 2013 e 54,43% (43/79) em 2014. A faixa et?ria mais acometida foi a de 21-30 anos (2013) e a de 11-20 anos (2014), com 25,77% (25/97) e 20,25% (16/79) dos casos positivos, respectivamente. A an?lise filogen?tica indicou que o gen?tipo V (DENV-1) e o gen?tipo II (DENV-4) circularam no Estado. Nossos resultados fornecem informa??es sobre a din?mica dos DENV no Rio Grande do Norte, importantes para o desenvolvimento de estrat?gias de controle da doen?a. === Dengue is an acute infectious disease, usually transmitted by Aedes aegypti mosquitoes. The etiologic agents belong to the family Flaviviridae, genus Flavivirus, and occur as four antigenically related but distinct serotypes designated DENV-1, 2, 3, and 4. In Brazil, the disease represents a national public health problem. The purpose of the present study was to describe epidemiological aspects of dengue in the State of Rio Grande do Norte, from 2013 to 2014. A total of 483 blood or serum samples, collected from January 2013 to December 2014, were studied by RT-PCR for viral detection and typing. The infection was confirmed in 36.44% (176/483) of the cases studied. This study detected the circulation of three serotypes of dengue virus in Rio Grande do Norte, DENV-1, 2, and 4. The predominant serotype in 2013-2014 was the DENV-4, representing 83.51% (81/97) and 68.35% (54/79) of the positive cases, respectively. Regarding the spatial distribution, most of the cases occurred in Natal and Caic?, with 9.28% (9/97) and 18.99% (15/79), respectively. The months with the biggest viral circulation in RN were March 2013 and May 2014. The female gender was the most affected, representing 69.07% (67/97) in 2013 and 54.43% (43/79) in 2014. The most affected age groups were 21-30 years (2013) and 11-20 years (2014) with 25.77% (25/97) and 20.25% (16/79) positive cases, respectively. Phylogenetic analysis indicated that genotype V (DENV-1) and genotype II (DENV-4) circulated in the State. Our results provide information about the dynamics of DENV in the Rio Grande do Norte, important for the development of disease control strategies.