Estudo epidemiol?gico da Toxoplasmose em gestantes atendidas na Maternidade Escola Janu?rio Cicco, Natal, Rio Grande do Norte

• Main Author: Barbosa, Isabelle Ribeiro
• Other Authors: CPF:59626305487
• Format: Others
• Language: Portuguese
• Published: Universidade Federal do Rio Grande do Norte 2015
• Subjects: Toxoplasmose; Gesta??o; Soropreval?ncia; MEIA; Toxoplasmosis; Pregnant women; Screening; Risk factors; CNPQ::CIENCIAS BIOLOGICAS
• Online Access: http://repositorio.ufrn.br:8080/jspui/handle/123456789/18537

Made available in DSpace on 2015-03-03T14:00:58Z (GMT). No. of bitstreams: 1 IsabelleRB.pdf: 1412800 bytes, checksum: bac7edd4cac638b6a9cf1189b964a174 (MD5) Previous issue date: 2008-08-12 === Congenital Toxoplasmosis results in severe systemic disease. If mother is infected for the first time during gestation, she can infect the fetus causing substantial damage. However, relatively little is known about the seroprevalence and epidemiological and economic factors of Toxoplasmosis infection in pregnancy in the most state in northeastern Brazil and knowledge about this can be essential in determining effective and acceptable prevention strategies. Our aim was to determine the prevalence of Toxoplasmosis in pregnant woman consulted by reference Maternity Escola Janu?rio Cicco in Natal, a city in Northeastern Brazil, which belongs to the public health system, correlating to the risk factors involved in the infection and to accomplish active Search in the Hospital of Pediatrics Prof? Heriberto Bezerra of the damages caused by the Toxoplasmic infection in children up to 12 years of age. The study was conducted from March to December 2007 and sera obtained from 190 pregnant women were tested for IgM and IgG antibodies avidity to Toxoplasma by Microparticle enzyme immunoassay (Abbott AxSYM system - Abbott Laboratories, Chicago, IL, USA). Data were examined with univariate analysis. Chi-squared (x2) and Odds ratio was calculated (IC 95% p 0,05). Of these women, 126 (66,3%) had only IgG antibodies high-avidity against T. gondii; 01 (0,52%) had a IgM and IgG high-avidity antibodies against T. gondii and 63 (33,1%) have neither IgM nor IgG against T. gondii. Our studies shown that the direct contact with cats or dogs was highly associated with the Toxoplasma gondii infection (OR, 2.72, p<0.001, 95% CI 1.46 5.02). The years school (p<0,001), socioeconomic status and knowledge about the disease (both p value 0.05) also were associated with Toxoplasmosis. The pattern of risk factors for infection presents regional variations, however our data corroborate others studies in Brazil. In children up to 12 years, one case of Congenital Toxoplasmosis was just registered in seven years (2000 - 2006). There were several suggestive cases, with signs and characteristic symptoms, but that the infection was not confirmed due to lack in the researches through laboratorial and images exams that addressed that it zoonosis === A Toxoplasmose cong?nita resulta em uma doen?a sist?mica severa. Devido ? m?e se infectar no primeiro trimestre da gesta??o, ela pode infectar o feto causando s?rios danos. Entretanto, h? pouca informa??o a respeito de soropreval?ncias e fatores econ?micos e epidemiol?gicos envolvidos na infec??o da gestante na maioria dos estados do Nordeste do Brasil e o conhecimento sobre isto pode ser essencial na determina??o e implementa??o de estrat?gias de preven??o. O objetivo desse trabalho foi determinar a preval?ncia da Toxoplasmose em gestantes atendidas na Maternidade Escola Janu?rio Cicco, em Natal, uma cidade do Nordeste do Brasil, correlacionando aos fatores de risco envolvidos na infec??o e realizar Busca ativa no Hospital de Pediatria Prof? Heriberto Bezerra dos agravos causados pela infec??o cong?nita e/ou p?s-natal por Toxoplasma gondii em crian?as at? 12 anos de idade. Esse estudo foi realizado de Mar?o a Dezembro de 2007 e o soro obtido das 190 gestantes foram testados para IgM e IgG antitoxoplasma pela t?cnica de Ensaio Imunoenzim?tico de Micropart?culas (Abbott AxSYM system - Abbott Laboratories, Chicago, IL, USA). Foi aplicada uma an?lise univariada no qual Qui-quadrado e Odds Ratio foram calculados (IC 95%, p 0,05). Das 190 mulheres, 126 (66,3%) tem somente IgG anti-Toxoplasma de alta avidez; 01(0,52%) tem IgM e IgG anti-Toxoplasma e 63 (33,1%) n?o tem nem IgM nem IgG de alta avidez anti-Toxoplasma. Esse estudo mostra que o contato direto com gatos ou c?es foi fortemente associado com a infec??o por Toxoplasma gondii (OR, 2.72, p<0.001, 95% CI 1.46 ? 5.02). Os anos de escolaridade (p<0,001), o status socioecon?mico e o conhecimento sobre a doen?a (ambos com p 0.05) tamb?m foram associados com a infec??o Toxopl?smica. O padr?o de fatores de risco para infec??o apresenta varia??es regionais, entretanto nossos dados corroboram outros estudos no Brasil. Em crian?as at? 12 anos, apenas um caso de Toxoplasmose cong?nita foi registrado em sete anos (2000 ? 2006). Houve diversos casos sugestivos, com sinais e sintomas caracter?sticos, mas que n?o foi confirmada a infec??o Toxopl?smica devido a car?ncia de aprofundamento nas pesquisas atrav?s de exames laboratoriais ou de imagem que direcionasse a essa zoonose