Obesidade, desregula??o insul?nica e lipidemia mista em equinos da ra?a mangalarga marchador

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Main Author:	Mello, Erica Bertha Fuhrich Raupp Bezerra de Mello
Other Authors:	Botteon, Paulo de Tarso Landgraf
Format:	Others
Language:	Portuguese
Published:	Universidade Federal Rural do Rio de Janeiro 2017
Subjects:	horse triglycerides hypercholesterolemia insulin dysfunction obesity equino trigliceridemia colesterolemia disfun??o insul?nica obesida Ci?ncias Agr?rias
Online Access:	https://tede.ufrrj.br/jspui/handle/jspui/1979

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record_format	oai_dc
collection	NDLTD
language	Portuguese
format	Others
sources	NDLTD
topic	horse triglycerides hypercholesterolemia insulin dysfunction obesity equino trigliceridemia colesterolemia disfun??o insul?nica obesida Ci?ncias Agr?rias
spellingShingle	horse triglycerides hypercholesterolemia insulin dysfunction obesity equino trigliceridemia colesterolemia disfun??o insul?nica obesida Ci?ncias Agr?rias Mello, Erica Bertha Fuhrich Raupp Bezerra de Mello Obesidade, desregula??o insul?nica e lipidemia mista em equinos da ra?a mangalarga marchador
description	Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2017-08-22T12:11:35Z No. of bitstreams: 1 2016 - Erica Bertha Fuhrich Raupp Bezerra de Mello.pdf: 1405623 bytes, checksum: 5fa531efb35b7236db276d4de4b56a2e (MD5) === Made available in DSpace on 2017-08-22T12:11:35Z (GMT). No. of bitstreams: 1 2016 - Erica Bertha Fuhrich Raupp Bezerra de Mello.pdf: 1405623 bytes, checksum: 5fa531efb35b7236db276d4de4b56a2e (MD5) Previous issue date: 2016-10-25 === Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES === Increased indicators of fat metabolism are found in Equine Metabolic Syndrome (EMS) subjects although these symptons are not included in the EMS definition described in the literature and in its diagnosis. 18 mares were allocated in three groups according to body condition status. In Group Ideal there were animals in fit condition (n=6), in Group Overweight, considered in overweight (n=6) and in Group Obese (n=6), animals considered obese. Fasting blood samples were taken to determine triglycerides, total cholesterol, glucose, and insulin concentrations in plasma. Insulin sensitivity proxy (RISQI) and ?-pancreatic secretion proxy (MIRG) were calculated from glucose and insulin data. There was a difference between groups in triglycerides levels (p<0.01), where Group Obese had significantly higher concentrations than other groups. Total cholesterol was higher in Group Obese compared to Group Ideal (p=0.01). No differences in plasma glucose (p=0.53) nor insulin (p = 0.10) concentrations and insulin sensitivity (RISQI: p=0.46) were seen among groups. Group Obese had a higher ?-pancreatic secretion (MIRG: p=0.05) compared to Group Ideal. The increased body condition score influenced the results of fat metabolites and ?-pancreatic secretion === O aumento das concentra??es de indicadores do metabolismo de gorduras ? bastante comum em casos diagnosticados de S?ndrome Metab?lica Equina (SME), mas apesar disto n?o entra no hall de fatores determinantes para diagn?stico da SME. Para avaliar a influ?ncia do escore corporal (EC) nas altera??es secund?rias associadas ? SME, foram avaliados lipidograma, glicemia, concentra??o de insulina, sensibilidade ? insulina (RISQI) e secre??o ?-pancre?tica de tr?s grupos de de ?guas Mangalarga Marchador n?o-getsantes/n?o-lactantes em tr?s diferentes categorias de EC (Ideal, Sobrepeso e Obeso). Cada grupo contou com 6 animais. Foram coletadas amostras de sangue em jejum de concentrado para a determina??o de concentra??o plasm?tica de triglicer?deos, colesterol total, glicose e insulina e a partir dos valores de glicemia e insulinemia foram calculados valores preditivos de sensibilidade ? insulina (RISQI) e secre??o ?-pancre?tica (MIRG). Houve diferen?a estat?stica entre os grupos quando avaliado os n?veis de triglicer?deos (p<0,01), sendo que o Grupo Obeso apesentou resultados significativamente superiores aos demais grupos. Foi observada diferen?a estat?stica entre os grupos quando avaliado as concentra??es de colesterol total (p=0,01), sendo que o Grupo Obeso apresentou resultados significativamente superiores ao Grupo Ideal. N?o foi observada diferen?a estat?stica entre os grupos nas concentra??es plasm?ticas de glicose (p=0,53) e insulina (p=0,10). N?o foi observada diferen?a estat?stica nos valores obtidos de RISQI (p=0,46), mas houve diferen?a estat?stica entre os grupos nos valores obtidos de MIRG (p=0,05), sendo que o Grupo Obeso obteve resultados significativamente superiores quando comparado com o Grupo Ideal. O escore corporal influenciou de forma positiva nos resultados do lipidograma e valor preditivo de secre??o ?-pancre?tica, sendo encontrados maiores n?veis em animais obesos.
author2	Botteon, Paulo de Tarso Landgraf
author_facet	Botteon, Paulo de Tarso Landgraf Mello, Erica Bertha Fuhrich Raupp Bezerra de Mello
author	Mello, Erica Bertha Fuhrich Raupp Bezerra de Mello
author_sort	Mello, Erica Bertha Fuhrich Raupp Bezerra de Mello
title	Obesidade, desregula??o insul?nica e lipidemia mista em equinos da ra?a mangalarga marchador
title_short	Obesidade, desregula??o insul?nica e lipidemia mista em equinos da ra?a mangalarga marchador
title_full	Obesidade, desregula??o insul?nica e lipidemia mista em equinos da ra?a mangalarga marchador
title_fullStr	Obesidade, desregula??o insul?nica e lipidemia mista em equinos da ra?a mangalarga marchador
title_full_unstemmed	Obesidade, desregula??o insul?nica e lipidemia mista em equinos da ra?a mangalarga marchador
title_sort	obesidade, desregula??o insul?nica e lipidemia mista em equinos da ra?a mangalarga marchador
publisher	Universidade Federal Rural do Rio de Janeiro
publishDate	2017
url	https://tede.ufrrj.br/jspui/handle/jspui/1979
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spelling	ndltd-IBICT-oai-localhost-jspui-19792019-01-22T00:50:35Z Obesidade, desregula??o insul?nica e lipidemia mista em equinos da ra?a mangalarga marchador Obesity, insulin deregulation and mixed lipidemia in horses of the mangalarga walker breed Mello, Erica Bertha Fuhrich Raupp Bezerra de Mello Botteon, Paulo de Tarso Landgraf Hess, Tanja Maria Faleiros, Rafael Resende Lessa, Daniel Augusto Barroso Almeida, Norma Aparecida dos Paiva, Jonimar Pereira horse triglycerides hypercholesterolemia insulin dysfunction obesity equino trigliceridemia colesterolemia disfun??o insul?nica obesida Ci?ncias Agr?rias Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2017-08-22T12:11:35Z No. of bitstreams: 1 2016 - Erica Bertha Fuhrich Raupp Bezerra de Mello.pdf: 1405623 bytes, checksum: 5fa531efb35b7236db276d4de4b56a2e (MD5) Made available in DSpace on 2017-08-22T12:11:35Z (GMT). No. of bitstreams: 1 2016 - Erica Bertha Fuhrich Raupp Bezerra de Mello.pdf: 1405623 bytes, checksum: 5fa531efb35b7236db276d4de4b56a2e (MD5) Previous issue date: 2016-10-25 Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES Increased indicators of fat metabolism are found in Equine Metabolic Syndrome (EMS) subjects although these symptons are not included in the EMS definition described in the literature and in its diagnosis. 18 mares were allocated in three groups according to body condition status. In Group Ideal there were animals in fit condition (n=6), in Group Overweight, considered in overweight (n=6) and in Group Obese (n=6), animals considered obese. Fasting blood samples were taken to determine triglycerides, total cholesterol, glucose, and insulin concentrations in plasma. Insulin sensitivity proxy (RISQI) and ?-pancreatic secretion proxy (MIRG) were calculated from glucose and insulin data. There was a difference between groups in triglycerides levels (p<0.01), where Group Obese had significantly higher concentrations than other groups. Total cholesterol was higher in Group Obese compared to Group Ideal (p=0.01). No differences in plasma glucose (p=0.53) nor insulin (p = 0.10) concentrations and insulin sensitivity (RISQI: p=0.46) were seen among groups. Group Obese had a higher ?-pancreatic secretion (MIRG: p=0.05) compared to Group Ideal. The increased body condition score influenced the results of fat metabolites and ?-pancreatic secretion O aumento das concentra??es de indicadores do metabolismo de gorduras ? bastante comum em casos diagnosticados de S?ndrome Metab?lica Equina (SME), mas apesar disto n?o entra no hall de fatores determinantes para diagn?stico da SME. Para avaliar a influ?ncia do escore corporal (EC) nas altera??es secund?rias associadas ? SME, foram avaliados lipidograma, glicemia, concentra??o de insulina, sensibilidade ? insulina (RISQI) e secre??o ?-pancre?tica de tr?s grupos de de ?guas Mangalarga Marchador n?o-getsantes/n?o-lactantes em tr?s diferentes categorias de EC (Ideal, Sobrepeso e Obeso). Cada grupo contou com 6 animais. Foram coletadas amostras de sangue em jejum de concentrado para a determina??o de concentra??o plasm?tica de triglicer?deos, colesterol total, glicose e insulina e a partir dos valores de glicemia e insulinemia foram calculados valores preditivos de sensibilidade ? insulina (RISQI) e secre??o ?-pancre?tica (MIRG). Houve diferen?a estat?stica entre os grupos quando avaliado os n?veis de triglicer?deos (p<0,01), sendo que o Grupo Obeso apesentou resultados significativamente superiores aos demais grupos. Foi observada diferen?a estat?stica entre os grupos quando avaliado as concentra??es de colesterol total (p=0,01), sendo que o Grupo Obeso apresentou resultados significativamente superiores ao Grupo Ideal. N?o foi observada diferen?a estat?stica entre os grupos nas concentra??es plasm?ticas de glicose (p=0,53) e insulina (p=0,10). N?o foi observada diferen?a estat?stica nos valores obtidos de RISQI (p=0,46), mas houve diferen?a estat?stica entre os grupos nos valores obtidos de MIRG (p=0,05), sendo que o Grupo Obeso obteve resultados significativamente superiores quando comparado com o Grupo Ideal. O escore corporal influenciou de forma positiva nos resultados do lipidograma e valor preditivo de secre??o ?-pancre?tica, sendo encontrados maiores n?veis em animais obesos. 2017-08-22T12:11:35Z 2016-10-25 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/doctoralThesis Mello, Erica Bertha Fuhrich Raupp Bezerra de Mello. Obesidade, desregula??o insul?nica e lipidemia mista em equinos da ra?a mangalarga marchador. 2016. [87 f.]. Tese( PROGRAMA DE P?S-GRADUA??O EM MEDICINA VETERIN?RIA (PATOLOGIA E CI?NCIAS CL?NICAS)) - Universidade Federal Rural do Rio de Janeiro, [Serop?dica-RJ] . https://tede.ufrrj.br/jspui/handle/jspui/1979 por ALBERTI KG, ZIMMET PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus: provisional report of a WHO consultation. Diabetic Medicine. v.15, n. 7, p.539?553, 1998 ALFORD, P.; GELLER, S.; RICHRDSON, B.; SLATER, M.; HONNAS, C.; FOREMAN, J.; ROBINSON, J.; MESSER, M.; ROBERTS, M.; GOBLE, D.; HOOD, D.;CHAFFIN, M. A multicenter, matched case-control study of risk factors for equine laminitis Preventive Veterinary Medicine v. 49, n. 3?4, p. 209-222, 2001 AMANN, R. P.; THOMPSON, D.L. JR; SQUIRES, E. L.; PICKETT, B. W. Effects of age and frequency of ejaculation on sperm production and extragonadal sperm reserves in stallions. Journal of Reproduction Fertility Supplement v. 27, p. 1-6, 1979 ARRUDA, A. M. V.; RIBEIRO, L. B.; PEREIRA, E. S.; BARRETO, J. C. Fracionamento dos nutrientes e digestibilidade da energia em alimentos alternativos com equinos adultos Caatinga v.21, n.1, p.01-10, 2008 ASSOCIA??O BRASILEIRA DE CRIADORES DE CAVALO MANGALARGA MARCHADOR, ABCCMM 2016 dispon?vel em http://www.abccmm.org.br/ (acessado em 14/09/2016) BAMFORD, N. J.; POTTER, S. J.; HARRIS, P. A.; BAILEY, S. R. Breed differences in insulin sensitivity and insulinemic responses to oral glucose in horses and ponies of moderate body condition score Domestic Animal Endocrinology v. 47, p. 101-107, 2014 BAMFORD, N. J.; POTTER, S. J.; HARRIS, P. A.; BAILEY, S. R. Effect of increased adiposity on insulin sensitivity and adipokine concentrations in horses and ponies fed a high fat diet, with or without a once daily high glycaemic meal Equine Veterinary Journal v. 48, p. 368?373, 2016 BODEN, G.; HOMKO, C.; BARRERO, C. A.; STEIN, T. P.; CHEN, X.; CHEUNG, P.; FECCHIO, C.; KOLLER, S.; MERALI, S. Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men Science Translational Medicine v. 7, n. 304, p. 304re7, 2015 BORER-WEIR, K. E; MENZIES-GOW, N. J.; BAILEY, S. R.; HARRIS, P. A.; ELLIOTT, J. Seasonal and annual influence on insulin and cortisol results from overnight dexamethasone suppression tests in normal ponies and ponies predisposed to laminitis Equine Veterinary Journal v. 45, n. 6, p. 688?693, 2013 CARNEVALE, E. M.; BERGFELT, D.R.; GINTHER, O.J. Aging effects on follicular activity and concentrations of FSH, LH, and progesterone in mares Animal Reproduction Science v. 31, n. 3?4, p. 287-299, 1993 CARTER, R. A. Thyroid status in exercising horses and laminitic ponies 2005 99f. Tese (Mestrado em Animal Sciences and Poultry Sciences) Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, 2005 31 CARTER, R. A.; GEOR, R. J.; STANIAR, W. B.; CUBITT, T. A.; HARRIS, P. A. Apparent adiposity assessed by standardised scoring systems and morphometric measurements in horses and ponies The Veterinary Journal v. 179, n. 2, p. 204-210, 2009a CARTER, R. A.; TREIBER, K. H.; GEOR, R. J.; DOUGLAS, L.; HARRIS, P. A. Prediction of incipient pasture-associaated laminitis from hyperinsulinemia, hyperleptinemia and generalized and localized obesity in a cohort of ponies Equine Veterinary Journal v. 41, n. 2, p. 171-178, 2009b CHATTERTON, N. J.; HARRISON, P. A.; BENNETT, J. H.; ASA, K. H. Carbohydrate partitioning in 185 accessions of Gramineae grown under warm and cool temperatures Journal of Plant Physiology v. 134, p. 169-179, 1989 COOPER, J. J.; MASON, G. J. The identification of abnormal behavior and behavioral problems in stabled horses and their relationship to horse welfare: a comparative review Equine Veterinary Journal Supplement n. 27, p. 5-9, 1998 COSTA, M.D.; BERGMANN, J.A.G.; RESENDE, A.S.C.; FONSECA, C.G.; FARIA, F.J.C. An?lise temporal da endogamia e do tamanho efetivo da popula??o de equinos da ra?a Mangalarga Marchador Arquivo Brasileiro de Medicina Veterin?ria e Zootecnia v.57, n.1, p.112-119, 2005b COSTA, M.D.; BERGMANN, J.A.G.; RESENDE, A.S.C.; FONSECA, C.G.; FARIA, F.J.C. Estudo da subdivis?o gen?tica da ra?a Mangalarga Marchador Arquivo Brasileiro de Medicina Veterin?ria e Zootecnia, v.57, n.2, p.272-280, 2005a DUGDALE, A. H. A.; GROVE-WHITE, D.; CURTIS, G. C.; HARRIS, P. A.; ARGO, C. M. C. G. Body condition scoring as a predictor of body fat in horses and ponies The Veterinary Journal v. 194, n 2, p. 173-178, 2012 DUNBAR, L. K.; MIELNICKI, K. A.; DEMBEK, K. A.; TORIBIO, R. E.; BURNS, T. A. Evaluation of four diagnostic tests for insulin dysregulation in adult light-breed horses Journal of Veterinary Internal Medicine v. 30, n. 3, p. 885-892, 2016 DURHAM, A. E. Metformin in equine metabolic syndrome: An enigma or a dead duck ? Guest Editorial The Veterinary Journal v.191, p. 17?18, 2012 DURHAM, A. E.; RENDLE, D. I.; NEWTON, J. R.The effect of metformin on measurements of insulin sensitivity and ? cell response in 18 horses and ponies withinsulin resistance Equine Veterinary Journal v. 40, n. 5, p. 493-500, 2008 ECKERSALL, P. D. Proteins, proteomics, and the dysprotinemias in clinical biochemestry of domestic animals In: KANEKO, J.J.; HARVEY, J.W.; BRUSS, M.L. (6a edi??o) Clinical Biochemistry of Domestic Animals San. Diego: Academic Press, 2008, p. 117-151 FEITOSA, F. L. F. Introdu??o ? semiologia In: FEITOSA, F. L. F. (2? edi??o) Semiologia Veterin?ria ? a arte do diagn?stico S?o Paulo: Editora ROCA 2008, p. 1-27 FLORES-RIVEROS, J. R.; McLENITHAN, J. C.; EZAKI, O.; LANE, M. D. Insulin down-regulates expression of the insulin-responsive glucose transporter (GLUT4) gene: Effects on 32 transcription and mRNA turnover Proceedings of the National. Academy of Sciences of the United States of America ? Biochemistry v. 90, p. 512-516, 1993 FRANK, N.; GEOR, R. J.; BAILEY, S. R.; DURHAM, A. E.; JOHNSON P. J. Equine Metabolic Syndrome Journal of Veterinary Internal Medicine v.24, p.467?475, 2010 FRANK, N.; TADROS, E. M. Insulin dysregulation Equine Veterinary Journal v. 46, p. 103?112, 2014 FRAPE, D. Estimando os requerimentos de nutrientes In: FRAPE, D., (3? edi??o) Nutri??o e Alimenta??o de Equinos S?o Paulo: Editora ROCA, 2007, p.175-228 FUNK, R. A.; WOOLDRIDGE, A. A.; STEWART, A. J., BEHREND, E. N.; KEMPPAINEN, R. J.; ZHONG, Q.; JOHNSON, A. K. Seasonal changes in the combined glucose-insulin tolerance test in normal aged horses Journal of Veterinary Internal Medicine v. 26, n. 4, p. 1035?1041, 2012 GEFFR?, A.; CONCORDET, D.; BRAUN, J. P.; TRUME, C. Reference Value Advisor: a new freeware set of macroinstructions to calculate reference intervals with Microsoft Excel Veterinary Clinical Pathology v. 40, n. 1, p. 107-112, 2011 GENTRY, L. R..; THOMPSON, Jr., D. L.; GENTRY, Jr, G. T.; DEL VECCHIO, R. P.; DAVIS, K. A.; DEL VECCHIO, P. M. The relationship between body condition score and ultrasonic fat measurements in mares of high versus low body condition Journal of Equine Veterinary Science v. 24, n. 5, p. 198-203, 2004 GEOR, R. J. Current concepts on the pathophysiology of pasture-associated laminitis Veterinary Clinics of North America: Equine Practice v. 26, n. 2, p. 265?276, 2010 HARRIS, P. A.; MARLIN, D. J.; GRAY, J. Plasma aspartate aminotransferase and creatine kinase activities in thoroughbred racehorses in relation to age, sex, exercise and training The Veterinary Journal v. 155, p. 295-304, 1998 HENNEKE, D. R POTTER, G. D.; KREIDER, J. L.; YEATES, B. F. Relation between condition score, physical measurements and body fat percentage in mares. Equine Veterinary Journal, v. 15, p. 371-372, 1983 HESS, T. M.; KRONFELD, D. S.; TREIBER ,K. H.; CRANDELL,K. E.; WALDRON, J. N.; WILLIAMS,C. A.; STANIAR, W. B.; LOPES, M. A.; HARRIS, P. A. Fat adaptation affects insulin sensitivity and elimination of horses during an 80 km endurance ride. Pferdeheilkunde v.23, n.3, p.241-246, 2007 HINCHCLIFF, K. W. e GEOR, R. J. Integrative physiology of exercise In: HINCHCLIFF, K. W. e GEOR, R. J (1a edi??o) Equine Sports Medicine and Surgery. Editora Saunders, 2004, p. 3-8 HOFFMAN, R. M.; BOSTON, R. C., STEFANOVSKI; KRONFELD, D. S.; HARRIS, Obesity and diet affect glucose dynamics and insulin sensitivity in Thoroughbred geldings. Journal of Animal Sciences v.81, p.2333-2342, 2003 33 JOHLIG, L.; VALBERG, S. J.; MICKELSON, J. R.; KLUKOWSKA, J.; REUSSER, H. R.; STRAUB, R.; GERBER, V. Epidemiological and genetic study of exertional rhabdomyolysis in a Warmblood horse family in Switzerland Equine Veterinary Journal v. 43, n. 2, p. 240?245, 2011 JOHNSON, P. J.; MESSER, N. T.; GANJAM, V. K. Cushing?s syndromes, insulin resistance and endocrinopathic laminitis Equine Veterinary Journal v. 36, n. 3, p. 194-198, 2004 JOHNSON, P. J.; WIEDMEYER, C. E.; LaCARRUBBA, A.; GANJAM, V. K.; MESSER, N. T. Laminitis and the Equine Metabolic Syndrome Veterinary Clinics os North America: Equine Practice v. 26, n. 2, p. 239-255, 2010 JOHNSON, P.J. The equine metabolic syndrome Peripheral Cushing's syndrome. Veterinary Clinics of North America: Equine Practice. v.18, n.2, p. 271-93, 2002 JOHNSON; P. J.; GANJAM, V. K.; MESSER, N. T.; TURK, J. R.; KEISLER, D. H.; BUFF, P. R.; WIEDMEYER, C. E. The obesity paradigm: an introduction to the emerging discipline of adipobiology. Proceedings of the 52nd Annual Convention of the American Association of Equine Practitioners; p. 41-50. 2006 JONES, L. S.; BERNDTSON, W. E. A quantitative study of Sertoli cell and germ cell populations as related to sexual development and aging in the stallion Biology of Reproduction v. 35, p. 138-148, 1986 JOSE-CUNILLERAS, E.; HINCHCLIFF,K. W.; LACOMBE, V. A. SAMS, R.A.; KOHN, C.W.; TAYLOR, L.E.; DEVOR, S.T. Ingestion of starch-rich meals after exercise increases glucose kinetics but fails to enhance muscle glycogen replenishment in horses. The Veterinary Journal, v.171, p.468?477, 2006 KEREM, N.; GUTTMANN, H.; HOCHBERG, Z. The autosomal trait of obesity, acanthosis nigricans, hypertension, ischemic heart disease and diabetes type 2 Hormone Research v. 55, p. 298-304, 2001 KRONFELD, D. S. Equine Syndrome X, the Metabolic Disease, and Equine Grain-Associated Disorders: Nomenclature and Dietetics. Journal of Equine Veterinary Science, v.23, n. 12, p.567-569, 2003 LANDE, R. Sexual dimorphism, sexual selection, and adaptation in polygenic characters Evolution v. 34, n. 2, p. 292-305, 1980 LINDHEIM, S. R.; DUFFY, D. M.; KOJIMA, T.; VIJOD, M. A.; STANCZYK, F. Z.; LOBO, R. A. The route of administration influences the effect of estrogen on insulin sensitivity in postmenopausal women Fertility and Sterility v. 62, n. 6, p. 1176-1180, 1994 MALINOWSKI, K.; BELTROS, C. L.; FLORA, L.; KEARNS, C. F.; McKEEVER, K. H. Effect of training on age-related changes in plasma insulin and glucose Equine Veterinary Journal v. 34, n. S34, p. 147-153, 2002 MARTIN-GIMENEZ, T.; DE BLAS, I.; AGUILERA-TEJERO, E.; DIEZ DE CASTRO, E.; AGUIRRE-PASCASIO, C. N. Endocrine, morphometric, and ultrasonographic 34 characterization of neck adiposity in Andalusian horses Domestic Animal Endocrinology v. 56, p. 57-62, 2016 McAFEE, L. M.; MILLS, D. S.; COOPER, J. J. The use of mirrors for the control of stereotypic weaving behaviour in the stabled horse Applied Animal Behaviour Science v. 78, n2-4, p. 158-173, 2002 McDONNEL, S. M. Behaviour of horses In: JENSENS, P. (1a edi??o) The Ethology of Domestic Animals ? An Introductory Text Oxfordshire: Editora CABI Pub, 2002 p.119-130 MELLO, E B F R B, Adapta??o ao exerc?cio em potros puro-sangue ingl?s de corrida 2012. 54 f. Disserta??o (Mestrado em Medicina Veterin?ria) ? Programa de P?s-Gradua??o em Medicina Veterin?ria. UFRRJ, Serop?dica, 2012 MELLO, E. B. F. R. B.; HESS, T. M.; TURNER, S. P.; SOUZA, B. G.; STELMANN, U. J. P.; SILVA, A. M. G. B; ALMEIDA, F. Q. Compara??o da sensibilidade ? insulina entre cavalos magros e normais Revista Oficial do Conselho Regional de Medicina Veterin?ria e Zootecnia ? MG (suplemento) v. 100, p. 115, 2009 MOREL, M. C. G. D.; NEWCOMBE, J. R.; SWINDLEHURST, J. C. The effect of age on multiple ovulation rates, multiple pregnancy rates and embryonic vesicle diameter in the mare Theriogenology v.63, p. 2482?2493, 2005 MURPHY, D.; REID, S. W.; LOVE, S. The effect of age on the oral glucose tolerance test in ponies Equine Veterinary Journal v. 29, n. 6, p. 467-170, 1997 NATIONAL ANIMAL HEALTH MONITORING SYSTEM, UNITED STATES DEPARTMENT OF AGRICULTURE Equine 2005. National health monitoring system, part 1: baseline reference of equine health and management. NAHMS USDA Colorado ? EUA, p.1-148, 2006 PARADIS, M. R. Demographics of health and disease in the geriatric horse The Veterinary Clinics, Equine Practice v. 18, p. 391?401, 2002 PARAVIDINO, A. B.; PORTELLA, E. S.; SOARES, E. A. Metabolismo energ?tico em atletas de endurance ? diferente entre os sexos Revista de Nutri??o, v. 20, n. 3, p. 317-325, 2007 PINTO, L. F. B.; ALMEIDA, F. Q.; QUIRINO, C. R.; CABRAL, G. C.; AZEVEDO, P. C. N.; SANTOS, E. M. An?lise multivariada das medidas morfom?tricas de potros da ra?a Mangalarga Marchador: an?lise discriminante Revista Brasileira de Zootecnia v.34, n.2, p.600-612, 2005 PRATT, S. E.; GEOR, R. J.; McCUTCHEON, L. J. Effects of dietary energy source and physical conditioning on insulin sensitivity and glucose tolerance in Standardbred horses. Equine Veterinary Journal Supplement v.36, p. 579-84, 2006 PRICE, J. S.; JACKSON, B.; EASTEL, R.; GOODSHIP, A. E.; BLUMSOHN, A.; WRIGHT, I.; STONEHAM, S.; LANYON, L. E.; RUSSEL, R. G. G. Age related changes in 35 biochemical markers of bone metabolism in horses Equine Veterinary Journal v. 27, n. 3, p. 201-207, 1995 QUINN, R. W.; BURK, A. O.; HARTSOCK, T. G.; PETERSEN, E. D.; WHITLEY, N. C.; TREIBER, K. H.; BOSTON, R. C. Insulin sensitivity in Thouroughbred geldings: effect of weight gain, diet, and exercise on insulin sensitivity in Thouroughbred geldings Journal of Equine Veterinary Sciences v. 28, n. 12, p. 728-738, 2008 RENDLE, D. I.; RUTLEDGE, F.; HUGHES, K. J.; HELLER, J.; DURHAM, A. E. Effects of metformin hydrochloride on blood glucose and insulin responses to oral dextrose in horses Equine Veterinary Journal v.45, p. 751-754, 2013 ROTH, J.; GLICK, S. M.; YALOW, R. S.; BERSON, S. A. Hypoglycemia: a potent stimulus to secretion of growth hormone Science v. 140, n. 3570, p. 987-988, 1963 S?NCHEZ, M. J.; AZOR, P. J.; MOLINA, A.; PARKIN, T.; RIVERO, J. L. L.; VALERA, M. Prevalence, risk factors and genetic parameters of cresty neck in Pura Raza Espa?ol horses Equine Veterinary Journal early view 2016 SILVA, S. R.; GUEDES, C. M.; COUTO, P.; SANTOS, A. S.; MELO-PINTO, P. Relationship between body condition and neck crest score systems and subcutaneous fat, tissue and muscle ultrasonic measurements in horses Annual Research & Review in Biology v. 4, n. 2, p. 354-365, 2014 SILVA, S. R.; GUEDES, C. M.; COUTO, P.; SANTOS, A. S.; MELO-PINTO, P. Relationship between body condition and neck crest score systems and subcutaneous fat, tissue and muscle ultrasonic measurements in horses In: Forages and grazing in horse nutrition, v. 132 Wageningen: Editora Wageningen Academic Publishers 2012, p. 381-386 STASHAK, T. Claudica??o In: STASHAK, T. S. (4? edi??o) Claudica??o em Equinos segundo Adams S?o Paulo: Editora ROCA, 1994, p. 503-821 STEWART, F.; GOODE, J. A.; ALLEN, W. R. Growth hormone secretion in the horse: unusual pattern at birth and pulsatile secretion through maturity Journal of Endocrinology v.138, p. 81-89, 1993 THATCHER, C. D.; PLEASANT, R. S.; GEOR, R. J.; ELVINGER, F. Prevalence of overconditioning in mature horses in southwest Virginia during the summer Journal of Veterinary Internal Medicine, 2012 TINWORTH, K. D.; BOSTON, R. C.; HARRIS, P. A.; SILLENCE, M. N.; RAIDAL, S. L.; NOBLE, G. K.The effect of oral metformin on insulin sensitivity in insulin-resistant ponies The Veterinary Journal v. 191, n. 1, p. 79-84, 2012 TREIBER, K. H.; HESS, T. M.; KRONFELD BOSTON, R.C.; GEOR, R.J.; FRIERE, M.; SILVA, A.M.G.B; HARRIS, P.A. Glucose dynamics during exercise: Dietary energy sources affect minimal model parameters in trained Arabian geldings during endurance exercise. Equine Veterinary Journal, v.36, p. 631-636, 2006c TREIBER, K. H.; KRONFELD, D. S.; GEOR, R. J. Insulin resistance in equids: possible role in laminitis. Journal of Nutrition v. 136; p. 2094S?2098S; 2006b 36 TREIBER, K. H.; KRONFELD, D. S.; HESS, T. . M.; BOSTON, R. C.; HARRIS, P. A. Use of proxies and reference quintiles obtained from minimal model analysis for determination of insulin sensitivity and pancreatic beta-cell responsiveness in horses. American Journal of Veterinary Research v.66, n.12, p.2114-2121, 2005 TREIBER, K. H.; KRONFELD, D. S.; HESS, T. M.; BYRD, B. M.; SPLAN, R. K.; STANIAR, W. B. Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies Journal of American Veterinary Medicine Association, v. 228, n. 10, 1538-1545, 2006a TURNER, S. P. Avalia??o da sensibilidade ? insulina em equinos de uso militar 2009 54f. Disserta??o (Mestrado em Zootecnia) ? Programa de P?s-Gradua??o em Zootecnia. UFRRJ, Serop?dica, 2009 VICK, M. M.; ADAMS, A. A.; MURPHY, B. A.; SESSIONS, D. R.; HOROHOV, D. W.; COOK, R. F.; SHELTON, B. J.; FITZGERALD, B. P.. Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse. Journal of Animal Sciences v.85, p.1144-1155, 2007 VICK, M. M.; SESSIONS, D. R.; MURPHY, B. A.; KENNEDY, E. L.; REEDY, S. E.; FITZGERALD, B. P. Obesity is associated with altered metabolic and reproductive activity in the mare: effects of metformin on insulin sensitivity and reproductive cyclicity Reproduction, Fertility and Development v.18, p.609?617, 2006 VOTION, D. M.; NAVET, R.; LACOMBE, V. A.; SLUSE, F.; GUSTAVSSON, B. E.; HINCHCLIFF, K. W.; RIVERO, J. L. L.; VALBERG, S. Muscle energetics in exercising horses Equine and Comparative Exercise Physiology v. 4, p. 105-118, 2008 WALLER, A. P.; LINDINGER, M. I. Nutritional aspects of post exercise skeletal muscle glycogen synthesis in horses: A comparative review Equine Veterinary Journal v. 42, n. 3, p. 274-281, 2010 WATTS, K. A. Forage and pasture management for laminitic horses Clinical Techniques in Equine Practice v. 3, n. 1, p. 88-95, 2004 WESTERVELT, R. G.; STOUFFER, J. R.; HINTZ, H. F.; SCHRYVER, H. F. Estimating fatness in horses and ponies Journal of Animal Sciences v. 43, p. 781-785, 1976 WILCOX, G. Insulin and Insulin Resistance. Clinical Biochemistry Review v.26, p.19-39, 2005 WITHAM, C. L.; STULL, C. L. Metabolic responses of chronically starved horses to refeeding with three isoenergetic diets Journal of American Veterinary Medicine Association v. 212, n. 5, 1998 WORLD HEALTH ORGANIZATION Definition, diagnosis and classification of Diabetes Mellitus and its complications WHO, Genebra ? Sui?a, p. 1-66, 1999 WORLD HEALTH ORGANIZATION Obesity WHO, 2012 dispon?vel em http://www.who.int/topics/obesity/en/, acessado em 24/02/2016 37 WYSE, C. A.; McNIE, K. A.; TANNAHIL, V. J.; MURRAY, J. K.; LOVE, S. Prevalence of obesity in riding horses in Scotland Veterinary Record v. 162, n. 18, p. 590-591, 2008 ZABEK, M. A.; BERMAN, D. M.; BLOMBERG, S. P.; COLLINS, C. W.; WRIGHT, J. Population dynamics of feral horses (Equus caballus) in an exotic coniferous plantation in Australia Wildlife Research v. 43, p. 358?367, 2016 ASPLIN, K. E.; SILLENCE, M. N.; POLLITT, C. C.; McGOWAN, C. M. Induction of laminitis by prolonged hyperinsulinaemia in clinically normal ponies The Veterinary Journal v. 174, p. 530?535, 2007 BANSE, H. E.; FRANK, N.; KWONG, G. P. S.; McFARLANE, D. Relationship of oxidative stress in skeletal muscle with obesity and obesity-associated hyperinsulinemia in horses The Canadian Journal of Veterinary Research v. 79, p. 329?338, 2015 BARON, A. D. Hemodynamics actions of insulin American Journal of Physiology v. 267, n.1, p. E187-E202, 1994 BARREIROS, A. L. B. S.; DAVID, J. M.; DAVID, J. P. Estresse oxidativo: rela??o entre gera??o de esp?cies reativas e defesa do organismo Quimica Nova v. 29, n. 1, p. 113-123, 2006 BASHAN, N.; KOVSAN, J.; KACHKO, I.; OVADIA, H.; RUDICH, A. positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species Physiology Review v. 89, p. 27?71, 2009 BIANCHI, P. D. Efeito da vitamina E sobre marcadores perif?ricos de estresse oxidativo em pacientes renais cr?nicos em hemodi?lise 2007, 179f. Tese (Doutorado em Ci?ncias Biol?gicas), Curso de P?s-Gradua??o em Ci?ncias Biol?gicas ? UFRGS, Porto Alegre, 2007 BOSTON, R. C.; STEFANOVSKI, D.; MOATE, P. J.; SUMNER, A.E.; WATANABE, R. M.; BERGMAN, R. N. MinMod Millennium: A computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test Diabetes Technology & Therapeutics v. 5, n. 6, 2003 BRADLEY, J. R. TNF-mediated inflammatory disease Journal of Pathology v. 214, p. 149-160, 2008 BRUNINI, T. M. C.; PERIM, N.; COSTA, E.; MENDES-RIBEIRO, A. C. O papel da via L-arginina-?xido n?trico em doen?as pulmonares Pulm?o RJ v. 15, n. 3, p. 184-190, 2006 BURNS, T.A.; WESTERMAN, T.; NUOVO, G.J.; WATTS, M. R.; PETTIGREW, A. YIN, C.; BELKNAP, J. K. Role of Oxidative tissue injury in the pathophysiology of experimentally induced equine laminitis: a comparison of 2 models Journal of Veterinary Internal Medicine v. 25, p.540?548, 2011 CANCELLO, R; CL?MENT, K Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue British Journal of Obstetrics and Gynaecology v. 113, n. 10, p. 1141?1147, 2006 CERIELLO, A.; MOTZ, E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arteriosclerosis, Thrombosis, and Vascular Biology v. 24, n. 5, p. 816-823. 2004 61 CONNERS, W.; WHITEBECK, C.; CHICESTER, P.; LEGGET, R.; YU LIN, A. D.; JOHNSON, A.; KOGAN, B.; LEVIN, R.; MANNIKAROTTU, A. L-NAME, a nitric oxide synthase inhibitor, diminishes oxidative damage in urinary bladder partial outlet obstruction American Journal of Physiology ? Renal Physiology v. 290, p. F357?F363, 2006. De LAAT , M. A.; MCGOWAN, C. M.; SILLENCE, M. N.; POLLITT, C. C. Hyperinsulinemic Laminitis Veterinary Clinic Equine v.26, p. 257?264, 2010b De LAAT, M. A.; McGOWAN, C. M.; SILLENCE, M. N.; POLLITT, C. C. Equine laminitis: Induced by 48 h hyperinsulinaemia in Standardbred horses Equine Veterinary Journal v. 42, n. 2, p. 129-135 2010a De LAAT, M.A.; KYAW-TANNER, M.T.; SILLENCE, M.N.; MCGOWAN, C.M.; POLLITT, C.C. Advanced glycation endproducts in horses with insulin-induced laminitis Veterinary Immunology and Immunopathology v. 145, p. 395? 401, 2012 DUNBAR, L. K.; MIELNICKI, K. A.; DEMBEK, K. A.; TORIBIO, R. E.; BURNS, T. A. Evaluation of four diagnostic tests for insulin dysregulation in adult light-breed horses Journal of Veterinary Internal Medicine v. 30, n. 3, p. 885-892, 2016 DURHAM, A. E.; HUGHES, K. J.; COTTLE, H. J.; RENDLE, D. I.; BOSTON, R. C. Type 2 Diabetes Mellitus with pancreatic cell dysfunction in 3 horses confirmed with minimal model analysis Equine Veterinary Journal v. 41, n. 9, p. 924-929, 2009 ECKERSALL, P. D. Proteins, proteomics, and the dysprotinemias in clinical biochemestry of domestic animals In: KANEKO, J.J.; HARVEY, J.W.; BRUSS, M.L. (6a edi??o) Clinical Biochemistry of Domestic Animals San. Diego: Academic Press, 2008, p. 117-151 EVANS, J. L.; GOLDFINE, I. D.; MADDUX, B. A.; GRODSKY, G. M. Are oxidative stress-activated signaling pathways mediators of insulin resistance and ?-cell dysfunction Diabetes v. 52, n. 1, p1-8, 2003 FANTUZZI, G Adipose tissue, adipokines, and inflammation Journal of Allergy and Clinical Immunology v. 115, n. 5, 2005 FEITOSA, F. L. F. Introdu??o ? semiologia In: FEITOSA, F. L. F. (2? edi??o) Semiologia Veterin?ria ? a arte do diagn?stico S?o Paulo: Editora ROCA 2008, p. 1-27 FRANK, N. Equine Metabolic Syndrome Journal of Equine Veterinary Science v. 29, n. 5, p. 259-267, 2009 FUJISAKA, S.; USUI, I.; IKUTANI, M.; AMINUDDIN, A.; TAKIKAWA, A.; TSUNEYAMA, K.; MAHMOOD, A.; GODA, N.; NAGAI, Y.; TAKATSU, K.; TOBE, K. Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1?-dependent and HIF-1?-independent manner in obese mice Diabetologia v. 56, n. 6, p. 1403?1412, 2013 GELONEZE, B.; TAMBASCIA, M. A. Avalia??o laboratorial e diagn?stico de resist?ncia insul?nica Arquivos Brasileiros de Endocrinologia & Metabologia v. 50, n. 2, p. 208-215, 2006 62 GON?ALVES, C. A. P. Apoptose de c?lulas epidermais lamelares em eq?inos com laminite induzida e tratados com anti-inflamat?rios n?o esteroidais 2009. 55f. Disserta??o (Mestrado em Medicina Veterin?ria), Programa de P?s Gradua??o em Medicina Veterin?ria, UFRRJ, Serop?dica, 2009 HENNEKE, D. R POTTER, G. D.; KREIDER, J. L.; YEATES, B. F. Relation between condition score, physical measurements and body fat percentage in mares. Equine Veterinary Journal, v. 15, p. 371-372, 1983. HOFFMAN, R. M.; BOSTON, R. C., STEFANOVSKI; KRONFELD, D. S.; HARRIS, Obesity and diet affect glucose dynamics and insulin sensitivity in Thoroughbred geldings. Journal of Animal Sciences v.81, p.2333-2342, 2003. JOHNSON, P. J.; MESSER, N. T.; GANJAM, V. K. Cushing?s syndromes, insulin resistance and endocrinopathic laminitis Equine Veterinary Journal v. 36, n. 3, p. 194-198, 2004 JOHNSON, P. J.; MESSER, N. T.; SLIGHT, S. H.; WIEDMEYER, C.; BUFF, P.; GANJAM, V. K. Endocrinopathic laminitis in the horse Clinical Techniques in Equine Practice v. 3, n. 1, p. 45-56 2004 JOHNSON, P. J.; SCOTTY, N. C.; WIEDMEYER, C.; MESSER, N. T.; KREEGER, J. M. Diabetes Mellitus in a domesticated Spanish Mustang Journal of the American Veterinary Medical Association v. 226, n. 4, p. 584-588, 2005 KAHN, C. R. Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction. Metabolism v. 27, p.1893?1902, 1978 KANEKI, M.; SHIMIZU, N.; YAMADA, D.; CHANG, K. Nitrosative stress and pathogenesis of insulin resistance Antioxidants and Redox Signaling v.9, n. 3, p. 319-329, 2007 KANEKO, J.J.; HARVEY, J.W.; BRUSS, M.L. Appendix VIII ? Blood analyte reference values in large animals In: KANEKO, J.J.; HARVEY, J.W.; BRUSS, M.L. (6a edi??o) Clinical Biochemistry of Domestic Animals San. Diego: Academic Press, 2008, 882-888 KEEN, J. A.; HILLIER, C.; MCGORUM, B. C.; NALLY, J. E. Endothelin mediated contraction of equine laminar veins Equine Veterinary Journal v.40, n. 5, p. 488-492, 2008 KIRSCHVINK, N.; MOFFARTS, B.; LEKEUX, P. The oxidant/antioxidant equilibrium in horses The Veterinary Journal v.177, p. 178?191, 2008 LINDNER, A. Use of blood biochemistry for positive performance diagnosis of sports horses practice Revue de M?decine V?t?rinairie v. 151, n. 7, p. 611-618, 2000 LYKKESFELD, J.; SVENDSEN, O. Oxidants and antioxidants in disease: oxidative stress in farm animals The Veterinary Journal v.173, p. 502?511, 2007 MAGALH?ES, J. F.; LIMA, I. R.; LIMA, L. R.; VARELA, J. A. R. C.; VIEIRA, R. A. M.; ALVES, G. E. S.; FALEIROS, R. R. Estudo da correla??o de medidas radiogr?ficas de laminite em ?guas da ra?a Mangalarga Marchador com e sem sinais de sobrepeso Arquivo Brasileiro de Medicina Veterin?ria e Zootecnia v. 66, n. 4, p. 1023-1032, 2014 63 MALLEM, M. Y.; THULEAU, A.; NOIREAUD, J.; DESFONTIS, J. C.; GOGNY, M. Evaluation of the role of superoxide anions in endotoxin-induced impairment of ?-adrenoceptor-mediated vasodilation in equine digital veins American Journal of Veterinary Research v. 71, n. 7, p. 773-779, 2010 McCUE, M. E.; GEOR, R. J.; SCHULTZ, N. Equine Metabolic Syndrome: a complex disease influenced by genetics and environment Journal of Equine Veterinary Science v. 35, p. 367-375, 2015 MELLO, E B F R B, Adapta??o ao exerc?cio em potros puro-sangue ingl?s de corrida 2012. 54 f. Disserta??o (Mestrado em Medicina Veterin?ria) ? Programa de P?s-Gradua??o em Medicina Veterin?ria. UFRRJ, Serop?dica, 2012 MUYLLE, E.; VAN DEN HENDE, C.; DEPREZ, P.; NUYTTEN, J.; OYAERT, W. Non-insulin dependent Diabetes Mellitus in a horse Equine Veterinary Journal v. 18, n. 2, p. 145-146, 1986 PACINI, G.; TONOLO, G.; SAMBATARO, M.; MAIOLI, M.; CICCARESE, M.; BROCCO, E.; AVOGARO, A.; NOSADINI, R. Insulin sensitivity and glucose effectiveness: minimal model analysis of regular and insulin-modified FSIGT American Journal of Physiology ? Endocrinology and Metabolism v. 274, p. 592-599, 1998. PAZ, C. F. R.; PAGANELA, J. C.; dos SANTOS, C. A.; NOGUEIRA, C. E. W.; FALEIROS, R. R. Rela??o entre obesidade, insulina plasm?tica e posicionamento de falange distal em equinos da ra?a Crioula Arquivo Brasileiro de Medicina Veterin?ria e Zootecnia v. 65, n. 6, p. 1699-1705, 2013 POLLITT, C. C. Equine laminitis Clinical Techniques in Equine Parctice v. 3, n. 1, p. 34-44, 2004 POLLITT, C. C. Laminitis in perspective In: POLLITT, C. C. (1a edi??o) Equine Laminitis ? Current Concepts Canberra: Editora: Rural Industries Research and Development Corporation 2008, p. 19-26 POLLITT, C. C. Update on the pathophysiology of laminitis 10th Geneva Congress of Equine Medicine and Surgery, Genebra, Sui?a, 2007 PRATT-PHILLIPS, S. E.; OWENS, K. M.; DOWLER, L. E.; CLONINGER, M. T. Assesment of resting insulin and leptin concentrations and their association with managerial and innate factors in horses Journal of Equine Veterinary Sciences v. 30, n. 3, p. 127-133, 2010 RADIN, M. J.; SHARKEY, L. C.; HOLYCROSS, B. J. Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses Veterinary Clinical Pathology v.38, n. 2, p. 136?156, 2009 RATTIGAN, S.; BUSSEY, C. T.; ROSS, R. M.; RICHARDS, S. M. Obesity, insulin resistance, and capillary recruitment Microcirculation, v.14, p. 299?309, 2007 SZABO, C. Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction British Journal of Pharmacology v. 156, p. 713?727, 2009 64 TILG, H.; MOSCHEN, A. R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity Nature Reviews Immunology v. 6, p. 772-783, 2006 TREIBER, K. H.; KRONFELD, D. S.; HESS, T. . M.; BOSTON, R. C.; HARRIS, P. A. Use of proxies and reference quintiles obtained from minimal model analysis for determination of insulin sensitivity and pancreatic beta-cell responsiveness in horses. American Journal of Veterinary Research v.66, n.12, p.2114-2121, 2005 TREIBER, K.; HESS, T. M., KRONFELD, D. S.; BOSTON, R. C.; GEOR, R.; HARRIS, P. A et al Insulin resistance and compensation in laminitis-predisposed ponies characterized by the Minimal Model Pferdeheilkunde v. 23, p. 237-240, 2007 TURNER, S. P.; HESS, T. M.; TREIBER, K.; MELLO, E. B.; SOUZA, B. G.; ALMEIDA, F. Q. Comparison of Insulin Sensitivity of Horses Adapted to Different Exercise Intensities Journal of Equine Veterinary Science v. 31, p. 645-649, 2011 VALLE, E.; D. STORACE, D.; SANGUINETI. R.; CARTER, R.; ODETTI, P.; GEOR, R.; BERGERO, D. Association of the glycoxidative stress marker pentosidine with equine laminitis The Veterinary Journal v. 196, p. 445-450, 2013 VICK, M. M.; ADAMS, A. A.; MURPHY, B. A.; SESSIONS, D. R.; HOROHOV, D. W.; COOK, R. F.; SHELTON, B. J.; FITZGERALD, B. P.. Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse. Journal of Animal Sciences v.85, p.1144-1155, 2007 VOTION, D. M.; NAVET, R.; LACOMBE, V. A.; SLUSE, F.; GUSTAVSSON, B. E.; HINCHCLIFF, K. W.; RIVERO, J. L. L.; VALBERG, S. Muscle energetics in exercising horses Equine and Comparative Exercise Physiology v. 4, p. 105-118, 2008 WANG, C. H.; WANG, C. C.; HUANG, H. C.; WEI, Y. H. Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes FEBS Journal v. 280, p. 1039?1050, 2013 WILCOX, G. Insulin and Insulin Resistance. Clinical Biochemistry Review v.26, p.19-39, 2005 WILLS, E. D. Mechanisms of lipid peroxide formation in animal tissues Biochemestry Journal v. 99, n. 3, p. 667-676, 1966 ZENG, G.; QUON, M. J. Insulin-stimulated production of nitric oxide is inhibited by Wortmannin The Journal of Clinical Investigation v. 98, n. 4, p. 894?898, 1996 ZHANG, L.; VINCENT, M. A.; RICHARDS, S. M.; CLERK, L. H.; RATTIGAN, S.; CLARK, M. G.; BARRETT, E. J. Insulin sensitivity of muscle capillary recruitment in vivo Diabetes v. 53, 2004 info:eu-repo/semantics/openAccess application/pdf Universidade Federal Rural do Rio de Janeiro Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas) UFRRJ Brasil Instituto de Veterin?ria reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ instname:Universidade Federal Rural do Rio de Janeiro instacron:UFRRJ

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