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Previous issue date: 2016 === A remo??o de terceiros molares inferiores retidos ? um procedimento invasivo com extenso trauma tecidual e resposta inflamat?ria p?s-operat?ria consider?vel. O objetivo deste estudo foi comparar o efeito da dexametasona 8mg (grupo controle) com o diclofenaco s?dico 50mg associados com fosfato de code?na 50mg (grupo experimental) para o controle da dor, edema e trismo, ap?s a exodontia dos terceiros molares inferiores impactados. Trinta terceiros molares inferiores de quinze pacientes saud?veis, com idade m?dia de 22,8 anos (desvio padr?o 12,62) receberam dose oral e ?nica de um dos f?rmacos uma hora antes de cada procedimento cir?rgico (dentes do lado esquerdo ou direito). Ap?s a cirurgia o edema foi aferido em 24, 48, 72 horas e 7 dias, sendo determinado por medidas lineares sobre o rosto, o trismo foi determinado pela abertura m?xima de boca. A dor p?s-operat?ria foi determinada pelo paciente atrav?s de uma escala visual de anal?gica, em intervalos de 24 horas, dentro de um per?odo total de 72 horas. A an?lise dos dados envolveu estat?stica descritiva, teste de Shapiro-Wilk, Wilcoxon, e teste T emparelhado (P<0,05). A dexametasona obteve melhores resultados nas an?lises de dor (p = 0,016) e edema (p = 0,08) no per?odo de 48 horas. N?o houve diferen?as estatisticamente significativas entre as drogas em rela??o ao trismo e ao n?mero de analg?sicos consumidos. Em conclus?o, a administra??o preventiva da dexametasona 8mg apresentou melhor controle da dor e edema nas exodontias bilaterais de terceiros molares inferiores impactados. === Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Odontologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2016. === Removing third retained molars is an invasive procedure with extensive tissue trauma and considerable postoperative inflammatory response. The aim of this study was to compare the effect of dexamethasone 8mg (control group) with diclofenac sodium 50mg associated with codeine phosphate 50 mg (experimental group) to control pain, swelling and trismus after extraction of third molars impacted. Thirty third molars fifteen healthy subjects with a mean age of 22.8 years (standard deviation 12.62) and received oral single dose of one of the drugs an hour before each surgery (teeth on the left or right). After surgery the edema was measured at 24, 48, 72 hours and 7 days, being determined by linear measurements on the face, trismus was determined by the maximum mouth opening. Postoperative pain was determined by the patient using a visual analogue scale at intervals of 24 hours, within a total period of 72 hours. The data analysis involved descriptive statistics, Shapiro-Wilk test, Wilcoxon test, and paired t-test (P <0.05). Dexamethasone better results in pain analysis (p = 0.016) and edema (p = 0.08) within 48 hours. There were no statistically significant differences between the drug relative to trismus, and the number of analgesics consumed. In conclusion, the preventive administration of dexamethasone 8mg showed better control of pain and edema in bilateral extractions of third molars impacted.
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