Cis-regulation and genetic control of gene expression in neuroblastoma

Cis-regulation and genetic control of gene expression in neuroblastoma

Genregulation beeinflusst Phänotypen im Kontext von Gesundheit und Krankheit. In Krebszellen regulieren genetische und epigenetische Faktoren die Genexpression in cis. Das Neuroblastom ist eine Krebserkrankung, die häufig im Kindesalter auftritt. Es ist gekennzeichnet durch eine geringe Anzahl exoni...

Full description

Bibliographic Details
Main Author:	Burkert, Christian Martin
Other Authors:	Ohler, Uwe
Format:	Doctoral Thesis
Language:	English
Published:	Humboldt-Universität zu Berlin 2021
Subjects:	Krebsgenomik Bioinformatik Neuroblastom Genregulation Epigenetik Genomsequenzierung Krebs Extrachromosomale zirkuläre DNA eQTL aseQTL Transcriptom ecDNA RNA-seq Quantitativer Merkmalslokus Genexpression Pathologie Medizin Erhaltung der Telomere Alternative Verlängerung der Telomere Onkologie Sequenzierung ganzer Genome WGS Molekularbiologie Quantitative Trait Locus Cancer genomics Computational biology Neuroblastoma Gene regulation Cancer Extrachromosomal circular DNA Whole-genome sequencing Bioinformatics Epigenetics Transcriptome Gene expression Pathology Medicine Telomere maintenance Alternative lengthening of telomeres Oncology Molecular biology 570 Biologie 610 Medizin und Gesundheit 004 Informatik 616 Krankheiten XH 8554 XH 8562 XH 8563 ddc:570 ddc:610 ddc:004 ddc:616
Online Access:	http://edoc.hu-berlin.de/18452/23696 http://nbn-resolving.de/urn:nbn:de:kobv:11-110-18452/23696-1 http://dx.doi.org/10.18452/23008

Similar Items

A vast resource of allelic expression data spanning human tissues
by: Stephane E. Castel, et al.
Published: (2020-09-01)

Extrachromosomal Circular DNA: Current Knowledge and Implications for CNS Aging and Neurodegeneration
by: Quratul Ain, et al.
Published: (2020-04-01)

Genetic control of longissimus dorsi muscle gene expression variation and joint analysis with phenotypic quantitative trait loci in pigs
by: Deborah Velez-Irizarry, et al.
Published: (2019-01-01)

Untersuchung des Einflusses mitochondrialer Polymorphismen auf die phänotypische Ausprägung der Neurofibromatose Typ 1 bei monozygoten Zwillingen
by: Detjen, Anne Katrin
Published: (2005)

Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes
by: Yehudit Hasin-Brumshtein, et al.
Published: (2016-09-01)

Next generation quantitative genetics in plants
by: José M Jiménez-Gómez
Published: (2011-11-01)

Genetical genomics of growth in a chicken model
by: Martin Johnsson, et al.
Published: (2018-01-01)

Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the Chicken
by: Martin Johnsson, et al.
Published: (2016-02-01)

Exploring the shallow end; estimating information content in transcriptomics studies
by: Daniel J Kliebenstein
Published: (2012-09-01)

Genetic variability of transcript abundance in pig peri-mortem skeletal muscle: eQTL localized genes involved in stress response, cell death, muscle disorders and metabolism
by: Liaubet Laurence, et al.
Published: (2011-11-01)

Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis
by: T. Maroilley, et al.
Published: (2017-12-01)

Sex-Interacting mRNA- and miRNA-eQTLs and Their Implications in Gene Expression Regulation and Disease
by: Jiangshan J. Shen, et al.
Published: (2019-04-01)

Beurteilung der Wirksamkeit einer präoperativen hyperthermen Radio-Chemotherapie beim lokal fortgeschrittenen Rektumkarzinom
by: Rau, Beate
Published: (1999)

Inferring genetic architecture of complex traits using Bayesian integrative analysis of genome and transcriptome data
by: Ehsani Alireza, et al.
Published: (2012-09-01)

Genetic Analysis of Methyl Anthranilate, Mesifurane, Linalool, and Other Flavor Compounds in Cultivated Strawberry (Fragaria × ananassa)
by: Christopher R. Barbey, et al.
Published: (2021-05-01)

Sequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure
by: Weitian Chen, et al.
Published: (2021-08-01)

Der Einfluss einer intravenösen Bolusapplikation versus einer Infusionstherapie von 1%, 2% und 3% Taurolidinlösung in der konventionellen Chirurgie auf das intra- und extraperitoneale Tumorwachstum bei Ratten
by: Schönbeck, Marco
Published: (2006)

Entwicklung und klinische Anwendung von Vakzinen unter Verwendung von DNA des Tumorantigens Muzin (MUC1)
by: Pecher, Gabriele
Published: (2003)

The impact of cell type and context-dependent regulatory variants on human immune traits
by: Zepeng Mu, et al.
Published: (2021-04-01)

Review: transcriptome and trans-omics analysis of systemic lupus erythematosus
by: Keishi Fujio, et al.
Published: (2020-06-01)

Prognostische Bedeutung des p53/Bax/p16 INK4a -Signalwegs bei Patienten mit kolorektalem Karzinom
by: Schelwies, Katharina
Published: (2005)

Expression der Cyclooxygenase-2 im Mammakarzinom
by: Müller, Berit Maria
Published: (2005)

Small ring has big potential: insights into extrachromosomal DNA in cancer
by: Yihao Wang, et al.
Published: (2021-04-01)

Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease
by: Jarrett D. Morrow, et al.
Published: (2018-01-01)

Selection of Transcripts Affecting Initial Growth Rate of Rice Backcrossed Inbred Lines Using RNA Sequencing Data
by: Akari Fukuda, et al.
Published: (2018-12-01)

Single-Nucleotide Polymorphisms Sequencing Identifies Candidate Functional Variants at Prostate Cancer Risk Loci
by: Peng Zhang, et al.
Published: (2019-07-01)

Multimodales Management maligner Ovarialtumore
by: Sehouli, Jalid
Published: (2005)

Telomere Replication: Solving Multiple End Replication Problems
by: Erin Bonnell, et al.
Published: (2021-04-01)

Alternative polyadenylation mediates genetic regulation of gene expression
by: Briana E Mittleman, et al.
Published: (2020-06-01)

Functional Annotation of Genetic Loci Associated With Sepsis Prioritizes Immune and Endothelial Cell Pathways
by: Kieu T. T. Le, et al.
Published: (2019-08-01)

Einfluss der Radikalität der Resektion eines Glioblastoma multiforme in Kombination mit einer adjuvanten Chemotherapie auf das Survival
by: Hubertus, Jochen
Published: (2005)

eQTL discovery and their association with severe equine asthma in European Warmblood horses
by: Victor C. Mason, et al.
Published: (2018-08-01)

Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative Analyses
by: Ancha Baranova, et al.
Published: (2021-09-01)

Sensitive detection of circular DNAs at single-nucleotide resolution using guided realignment of partially aligned reads
by: Iñigo Prada-Luengo, et al.
Published: (2019-12-01)

Wert der MR-angiographischen Technik für die Dignitätsbeurteilung von Ovarialraumforderungen
by: Stuhlemmer, Katja
Published: (2006)

Extrachromosomal Circular DNA from TCGA Tumors Is Generated from Common Genomic Loci, Is Characterized by Self-Homology and DNA Motifs near Circle Breakpoints
by: Black, J.C, et al.
Published: (2022)

Highly diversified core promoters in the human genome and their effects on gene expression and disease predisposition
by: Hemant Gupta, et al.
Published: (2020-11-01)

From integrative genomics to systems genetics in the rat to link genotypes to phenotypes
by: Aida Moreno-Moral, et al.
Published: (2016-10-01)

Enhancing the Promise of Drug Repositioning through Genetics
by: Jayne-Louise E. Pritchard, et al.
Published: (2017-12-01)

Powerful eQTL mapping through low-coverage RNA sequencing
by: Boks, M.P, et al.
Published: (2022)