Entwicklung molekularer Werkzeuge zur Erforschung des Lipidstoffwechsels

Entwicklung molekularer Werkzeuge zur Erforschung des Lipidstoffwechsels

Im Rahmen dieser Arbeit wurden fluoreszierende Sphingomyelin-Analoga zu Studium der sauren Sphingomyelinase (ASM) synthetisiert. Ausgehend von L-Serin wurde ein Sphingosin-Derivat mit natürlicher Stereochemie dargestellt. Anschließend wurde mittels Phosphorodichloridat-Chemie eine Aminoethylphosphat...

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Bibliographic Details
Main Author:	Pinkert, Thomas
Other Authors:	Mahrwald, Rainer
Format:	Doctoral Thesis
Language:	German
Published:	Humboldt-Universität zu Berlin 2017
Subjects:	Enzyme Saure Sphingomyelinas Phospholipide Sphingolipide Sphingomyelin Ceramid Fluoreszenz Förster-Resonanzenergietransfer (FRET) Fluoreszenz-basierte Assays Murine Embryonale Fibroblasten (MEF) Zweiphotonenfluoreszenzmikroskopie Enzymes Acid Sphingomyelinase Phospholipids Sphingolipids Ceramide Fluorescence Förster-Resonance Energy Transfer (FRET) Fluorescence-based Assays Mouse Embryonic Fibroblasts (MEF) Two-photon Fluorescence Microscopy 547 Organische Chemie VK 8707 WD 5050 VG 8757 ddc:547
Online Access:	http://edoc.hu-berlin.de/18452/18698 http://nbn-resolving.de/urn:nbn:de:kobv:11-110-18452/18698-5 http://dx.doi.org/10.18452/18034

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