Modulation of human antigen-specific T cell response - therapeutic implications for multiple sclerosis

Modulation of human antigen-specific T cell response - therapeutic implications for multiple sclerosis

Multiple Sklerose (MS) ist eine heterogene Krankheit des Zentralnervensystems, deren pathologische Mechanismen noch nicht vollständig aufgeklärt sind. Die gegenwärtige Hypothese ist, daß pro-inflammatorische T-Zellen entscheidend an der Pathogenese der MS beteiligt sind. Man geht davon aus, daß eine...

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Bibliographic Details
Main Author:	Waiczies, Sonia
Other Authors:	Zipp, Frauke
Format:	Doctoral Thesis
Language:	English
Published:	Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité 2003
Subjects:	Proliferation Apoptose Zellzyklus Multiple Sklerosis T-Zellen MS Therapeutische Strategien Therapien T-Zell-Aktivierung AICD Bcl-2-Familie Bcl-XL DNA-Fragmentierung Immunomodulatoren Todesliganden TRAIL Statine Atorvastatin HMG-CoA-Reduktaseweges CDK4 p27Kip1 CRAC-Kanäle Kalzium-Ionen immunomodulation therapy T cells cell cycle Multiple sclerosis therapeutic strategies T cell activation T cell proliferation T cell elimination Bcl-2 family activation-induced cell death DNA fragmentation TNF/NGF family death ligand TNF-related apoptosis inducing ligand atorvastatin HMG-CoA reductase pathway progression G1/S thapsigargin calcium-release activated calcium channels CRAC channels calcium influx immunomodulatory agents 610 Medizin 33 Medizin ddc:610
Online Access:	http://edoc.hu-berlin.de/18452/15627 http://nbn-resolving.de/urn:nbn:de:kobv:11-10020593 http://dx.doi.org/10.18452/14975

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