Design and synthesis of small molecules and nanoparticle conjugates for cell type-selective delivery

Design and synthesis of small molecules and nanoparticle conjugates for cell type-selective delivery

Histone deacetylase (HDAC) inhibition is an emerging novel therapeutic strategy in cancer therapy. HDAC inhibitors (HDACi) have shown ability to block angiogenesis and cell cycling, as well as initiate differentiation and apoptosis. In fact, suberoylanilide hydroxamic acid (SAHA) is the first in t...

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Bibliographic Details
Main Author: Chen, Po Chih
Published: Georgia Institute of Technology 2009
Subjects:
Histone deacetylase
Gold nanoparticles
Penicillin
Click chemistry
Diazo-transfer reaction
Nonpeptide macrolide
Bioconjugates
Molecules
Nanostructures
Bioavailability
Drug delivery systems
Online Access:http://hdl.handle.net/1853/28111

Internet

http://hdl.handle.net/1853/28111

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