Mechanistic numerical study of trhombus growth

A computational model of thrombus initiation and aggrandizement was proposed. The model separated the thrombotic process into three mechanisms, including shear enhanced diffusivity, platelet margination, and platelet adhesion. The model indicates that transport mechanisms may be the rate limiting...

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Main Author:	Bark, David Lawrence, Jr.
Published:	Georgia Institute of Technology 2008
Subjects:	Diffusion Adhesion Arteriosclerosis Atherosclerosis Platelet Thrombosis Thrombus Blood Computational fluid dynamics Blood platelets Transport theory Cell adhesion Shear flow
Online Access:	http://hdl.handle.net/1853/22550

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spelling	ndltd-GATECH-oai-smartech.gatech.edu-1853-225502013-01-07T20:25:48ZMechanistic numerical study of trhombus growthBark, David Lawrence, Jr.DiffusionAdhesionArteriosclerosisAtherosclerosisPlateletThrombosisThrombusBloodThrombosisComputational fluid dynamicsBlood plateletsTransport theoryCell adhesionShear flowA computational model of thrombus initiation and aggrandizement was proposed. The model separated the thrombotic process into three mechanisms, including shear enhanced diffusivity, platelet margination, and platelet adhesion. The model indicates that transport mechanisms may be the rate limiting condition of thrombus formation at physiological shear rates and that at higher shear rates; platelet binding becomes the rate limiting condition. Additionally a wall shear rate of 20000 s-1 and above should be considered as a new criterion for prophylactic treatment of an atherosclerotic lesion.Georgia Institute of Technology2008-06-10T20:36:28Z2008-06-10T20:36:28Z2007-04-19Thesishttp://hdl.handle.net/1853/22550
collection	NDLTD
sources	NDLTD
topic	Diffusion Adhesion Arteriosclerosis Atherosclerosis Platelet Thrombosis Thrombus Blood Thrombosis Computational fluid dynamics Blood platelets Transport theory Cell adhesion Shear flow
spellingShingle	Diffusion Adhesion Arteriosclerosis Atherosclerosis Platelet Thrombosis Thrombus Blood Thrombosis Computational fluid dynamics Blood platelets Transport theory Cell adhesion Shear flow Bark, David Lawrence, Jr. Mechanistic numerical study of trhombus growth
description	A computational model of thrombus initiation and aggrandizement was proposed. The model separated the thrombotic process into three mechanisms, including shear enhanced diffusivity, platelet margination, and platelet adhesion. The model indicates that transport mechanisms may be the rate limiting condition of thrombus formation at physiological shear rates and that at higher shear rates; platelet binding becomes the rate limiting condition. Additionally a wall shear rate of 20000 s-1 and above should be considered as a new criterion for prophylactic treatment of an atherosclerotic lesion.
author	Bark, David Lawrence, Jr.
author_facet	Bark, David Lawrence, Jr.
author_sort	Bark, David Lawrence, Jr.
title	Mechanistic numerical study of trhombus growth
title_short	Mechanistic numerical study of trhombus growth
title_full	Mechanistic numerical study of trhombus growth
title_fullStr	Mechanistic numerical study of trhombus growth
title_full_unstemmed	Mechanistic numerical study of trhombus growth
title_sort	mechanistic numerical study of trhombus growth
publisher	Georgia Institute of Technology
publishDate	2008
url	http://hdl.handle.net/1853/22550
work_keys_str_mv	AT barkdavidlawrencejr mechanisticnumericalstudyoftrhombusgrowth
_version_	1716474810302726144

Mechanistic numerical study of trhombus growth

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