The Role of the Α7 and Α4β2 Nicotinic Receptors in Nicotine Sensitization and Neural Plasticity of Adolescent Rats Neonatally Treated with Quinpirole: Effects on Mtor and Nicotinic Receptor Density

The Role of the Α7 and Α4β2 Nicotinic Receptors in Nicotine Sensitization and Neural Plasticity of Adolescent Rats Neonatally Treated with Quinpirole: Effects on Mtor and Nicotinic Receptor Density

Aims: (1) Analyze the roles of α7 and α4β2 nicotinic receptors (nAChRs) in nicotine sensitization in adolescent male and female rats neonatally treated with quinpirole as well as their effects on brain-derived neurotrophic factor (BDNF) and mammalian target of rapamycin (mTOR) 1 h and 24 h post drug...

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Bibliographic Details
Main Authors: Peterson, Daniel J., Wherry, Jim, Cummins, Elizabeth D., Hoover, Don, Brown, Russell W.
Published: Digital Commons @ East Tennessee State University 2017
Subjects:
nicotinic receptors
Biomedical Sciences
Substance Abuse and Addiction
Online Access:https://dc.etsu.edu/etsu-works/2769
https://doi.org/10.1016/j.drugalcdep.2016.08.453

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