The Effects of Nicotine in the Neonatal Quinpirole Rodent Model of Psychosis: Neural Plasticity Mechanisms and Nicotinic Receptor Changes

The Effects of Nicotine in the Neonatal Quinpirole Rodent Model of Psychosis: Neural Plasticity Mechanisms and Nicotinic Receptor Changes

Neonatal quinpirole (NQ) treatment to rats increases dopamine D2 receptor sensitivity persistent throughout the animal’s lifetime. In Experiment 1, we analyzed the role of α7 and α4β2 nicotinic receptors (nAChRs) in nicotine behavioral sensitization and on the brain-derived neurotrophic factor (BDNF...

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Bibliographic Details
Main Authors: Peterson, Daniel J., Gill, Wesley Drew, Dose, John M., Hoover, Donald B., Pauly, James R., Cummins, Elizabeth D., Burgess, Katherine C., Brown, Russell W.
Published: Digital Commons @ East Tennessee State University 2017
Subjects:
adolescence
brain-derived neurotrophic factor (BDNF)
dopamine D2 receptor
nicotine sensitization
α4β2 nicotinic receptor
α7 nicotinic receptor
Biomedical Sciences
Neurosciences
Substance Abuse and Addiction
Online Access:https://dc.etsu.edu/etsu-works/942
https://doi.org/10.1016/j.bbr.2017.02.029

Internet

https://dc.etsu.edu/etsu-works/942
https://doi.org/10.1016/j.bbr.2017.02.029

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