An Analysis of the Rewarding and Aversive Associative Properties of Nicotine in the Neonatal Quinpirole Model: Effects on Glial Cell Line-Derived Neurotrophic Factor (GDNF)

An Analysis of the Rewarding and Aversive Associative Properties of Nicotine in the Neonatal Quinpirole Model: Effects on Glial Cell Line-Derived Neurotrophic Factor (GDNF)

This study analyzed the associative properties of nicotine in a conditioned place preference (CPP) paradigm in adolescent rats neonatally treated with quinpirole (NQ) or saline (NS). NQ produces dopamine D2 receptor supersensitivity that persists throughout the animal's lifetime, and therefore...

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Bibliographic Details
Main Authors: Brown, Russell W., Kirby, Seth L., Denton, Adam R., Dose, John M., Cummins, Elizabeth D., Gill, Wesley Drew, Burgess, Katherine C.
Published: Digital Commons @ East Tennessee State University 2017
Subjects:
adolescence
antipsychotics
conditioned place preference
dopamine D2 receptor
nicotine
schizophrenia
Biomedical Sciences
Neurosciences
Substance Abuse and Addiction
Online Access:https://dc.etsu.edu/etsu-works/940
https://doi.org/10.1016/j.schres.2017.03.024

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