A novel role of human DNA damage checkpoint protein ATR in suppressing Ca2+ overload-induced PARP1-mediated necrosis
Ataxia telangiectasia and Rad3-related (ATR) is well known for its regulatory role in DNA damage responses (DDR) as a checkpoint kinase that phosphorylates hundreds of protein substrates. However, its role in cellular non-DNA damage stress responses (NDDR) is unknown. Necrosis is one form of cell de...
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| Format: | Others |
| Language: | English |
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Digital Commons @ East Tennessee State University
2016
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| Online Access: | https://dc.etsu.edu/etd/3171 https://dc.etsu.edu/cgi/viewcontent.cgi?article=4580&context=etd |