Toward the Synthesis of Nuclease Models.

Nucleases are enzymes that can specifically recognize nucleic acids and hydrolyze their phosphodiester bonds effectively. As is the case with many hydrolases, nucleases often carry one or more metal centers. Cooperation between such metal centers and other interactions involving general acid-base ac...

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Main Author:	Fomumbod, Enni Nina
Format:	Others
Published:	Digital Commons @ East Tennessee State University 2008
Subjects:	synthetic probe metallonuclease Synthetic nuclease Chemicals and Drugs Enzymes and Coenzymes Medicine and Health Sciences
Online Access:	https://dc.etsu.edu/etd/1912 https://dc.etsu.edu/cgi/viewcontent.cgi?article=3264&context=etd

id	ndltd-ETSU-oai-dc.etsu.edu-etd-3264
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spelling	ndltd-ETSU-oai-dc.etsu.edu-etd-32642019-05-16T04:43:03Z Toward the Synthesis of Nuclease Models. Fomumbod, Enni Nina Nucleases are enzymes that can specifically recognize nucleic acids and hydrolyze their phosphodiester bonds effectively. As is the case with many hydrolases, nucleases often carry one or more metal centers. Cooperation between such metal centers and other interactions involving general acid-base activities are believed to be essential in multifunctional catalyses. Combination of such interactions in model compounds often resulted in larger than additive effects. This work is aimed at synthesizing nuclease models that combine the ability to recognize phosphate groups and/or nitrogen bases of DNA together with the ability to catalyze phosphodiester hydrolysis. These models were designed to achieve optimum interaction between the recognition and the catalytic functionalities. Towards this goal, we chose phenonthiazonium ions (methylene blue analogues) and anthracene as spacers. 2008-05-03T07:00:00Z text application/pdf https://dc.etsu.edu/etd/1912 https://dc.etsu.edu/cgi/viewcontent.cgi?article=3264&context=etd Copyright by the authors. Electronic Theses and Dissertations Digital Commons @ East Tennessee State University synthetic probe metallonuclease Synthetic nuclease Chemicals and Drugs Enzymes and Coenzymes Medicine and Health Sciences
collection	NDLTD
format	Others
sources	NDLTD
topic	synthetic probe metallonuclease Synthetic nuclease Chemicals and Drugs Enzymes and Coenzymes Medicine and Health Sciences
spellingShingle	synthetic probe metallonuclease Synthetic nuclease Chemicals and Drugs Enzymes and Coenzymes Medicine and Health Sciences Fomumbod, Enni Nina Toward the Synthesis of Nuclease Models.
description	Nucleases are enzymes that can specifically recognize nucleic acids and hydrolyze their phosphodiester bonds effectively. As is the case with many hydrolases, nucleases often carry one or more metal centers. Cooperation between such metal centers and other interactions involving general acid-base activities are believed to be essential in multifunctional catalyses. Combination of such interactions in model compounds often resulted in larger than additive effects. This work is aimed at synthesizing nuclease models that combine the ability to recognize phosphate groups and/or nitrogen bases of DNA together with the ability to catalyze phosphodiester hydrolysis. These models were designed to achieve optimum interaction between the recognition and the catalytic functionalities. Towards this goal, we chose phenonthiazonium ions (methylene blue analogues) and anthracene as spacers.
author	Fomumbod, Enni Nina
author_facet	Fomumbod, Enni Nina
author_sort	Fomumbod, Enni Nina
title	Toward the Synthesis of Nuclease Models.
title_short	Toward the Synthesis of Nuclease Models.
title_full	Toward the Synthesis of Nuclease Models.
title_fullStr	Toward the Synthesis of Nuclease Models.
title_full_unstemmed	Toward the Synthesis of Nuclease Models.
title_sort	toward the synthesis of nuclease models.
publisher	Digital Commons @ East Tennessee State University
publishDate	2008
url	https://dc.etsu.edu/etd/1912 https://dc.etsu.edu/cgi/viewcontent.cgi?article=3264&context=etd
work_keys_str_mv	AT fomumbodenninina towardthesynthesisofnucleasemodels
_version_	1719188133381144576

Toward the Synthesis of Nuclease Models.

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