Analysis of TCR Signaling and Erk Activation in T Cell Development and Autoimmunity
<p><p>LAT is a transmembrane adaptor protein that is critical for the emanation of signals downstream of the TCR. Following TCR engagement, LAT is phosphorylated on multiple tyrosine residues, allowing it to serve as a scaffold for a multi-protein signaling complex. Mutation of tyrosine...
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2012
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| Online Access: | http://hdl.handle.net/10161/5772 |