Analysis and Redesign of Protein-Protein Interactions: A Hotspot-Centric View
<p><p>One of the most significant discoveries from mutational analysis of protein interfaces is that often a large percentage of interface residues negligibly perturb the binding energy upon mutation, while residues in a few critical "hotspots" drastically reduce affinity when...
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2010
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| Online Access: | http://hdl.handle.net/10161/3113 |