Exercise-induced changes in basal ganglia volume and their relation to cognitive performance

• Main Authors: Becker, Linda, Kutz, D. F., Voelcker-Rehage, Claudia
• Other Authors: TU Chemnitz, Fakultät für Human- und Sozialwissenschaften
• Format: Article
• Language: English
• Published: Universitätsbibliothek Chemnitz 2016
• Subjects: Kognition; Basalganglien; körperliche Aktivität; Altern; Technische Universität Chemnitz; Publikationsfonds; cognition; basal ganglia; physical activity; aging; Publication funds; ddc:614; Körperliche Aktivität
• Online Access: http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-213533; http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-213533; http://www.qucosa.de/fileadmin/data/qucosa/documents/21353/becker_exercise-induced_jneurology.pdf; http://www.qucosa.de/fileadmin/data/qucosa/documents/21353/signatur.txt.asc

Physical activity, especially cardiovascular fitness training, has been shown to enhance cognitive performance and to counteract age-related cognitive decline1-5. Furthermore, regular physical activity has been demonstrated to diminish age-related volume-shrinkage in several brain regions particularly in the prefrontal cortex and hippocampus6-10. In the same vein, physical activity and high levels of cardiovascular fitness seem to enhance neurocognition during childhood11-13. In this context, the basal ganglia and its components, the caudate nucleus, the putamen and the globus pallidus, are of special interest as animal research indicates that exercise also seems to influence the molecular architecture and the metabolic capacity of the basal ganglia14,15. Besides their fundamental role in motor execution16, the basal ganglia are also involved in many cognitive functions like mental flexibility17, task-switching ability18 and cognitive control19. Furthermore, age-related disorders like Parkinson’s disease are related to a decline in the dopamine circuits of the basal ganglia20,21. The striatum is the input nucleus of the basal ganglia and is composed of caudate nucleus and putamen. The pars interna of the globus pallidus is (together with the substantia nigra pars reticulata) the output region of the basal ganglia and conveys information from the striatum to the thalamus and back to the frontal areas22. The striatum, which is essential for cognitive flexibility and attentional control, shows an increase during childhood and adolescence23,24 and a particularly rapid and early age-related change9,25 in older adults. Furthermore, the described cognitive functions are essential for academic success of children and young adults. Thus, it is of particular interest to find appropriate interventions that could mitigate both the volume-shrinkage and the (presumably) related cognitive decline in older adults and/or that could support academic success in children. In this review, we will summarize research that investigated whether physical activity has the potential to be such an intervention. First, we will show that neuroplasticity in the basal ganglia is possible in principle. Second, we will report studies where the relationship between physical fitness level and volume of the basal ganglia and its relation to cognitive performance were investigated. Besides cross-sectional studies, we will report studies that investigated exercise-induced changes in the volume of the basal ganglia and related changes in cognitive performance after long-term fitness interventions.