Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer

Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer

Bivalent (poised or paused) chromatin comprises activating and repressing histone modifications at the same location. This combination of epigenetic marks at promoter or enhancer regions keeps genes expressed at low levels but poised for rapid activation. Typically, DNA at bivalent promoters is only...

Full description

Bibliographic Details
Main Authors:	Bernhart, Stephan H., Kretzmer, Helene, Holdt, Lesca M., Jühling, Frank, Ammerpohl, Ole, Bergmann, Anke K., Northoff, Bernd H., Doose, Gero, Siebert, Reiner, Stadler, Peter F., Hoffmann, Steve
Other Authors:	Universität Leipzig, Fakultät für Mathematik und Informatik
Format:	Article
Language:	English
Published:	Universitätsbibliothek Leipzig 2016
Subjects:	Chromatin Krebs bivalent chromatin cancer ddc:601
Online Access:	http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-215991 http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-215991 http://www.qucosa.de/fileadmin/data/qucosa/documents/21599/OAP-2016-187_Bernhart_srep37393.pdf

Similar Items

Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells
by: Donnchadh S. Dunican, et al.
Published: (2020-03-01)

Dynamics of promoter bivalency and RNAP II pausing in mouse stem and differentiated cells
by: Anna Mantsoki, et al.
Published: (2018-02-01)

Chromatin signature of widespread monoallelic expression
by: Anwesha Nag, et al.
Published: (2013-12-01)

Bivalent genes that undergo transcriptional switching identify networks of key regulators of embryonic stem cell differentiation
by: Ah-Jung Jeon, et al.
Published: (2020-11-01)

Synthetic CpG islands reveal DNA sequence determinants of chromatin structure
by: Elisabeth Wachter, et al.
Published: (2014-09-01)

Régulation et fonction de la chromatine bivalente chez les mammifères : l'emprunte parentale comme modèle.
by: Montibus, Bertille
Published: (2016)

Marek’s disease virus infection induces widespread differential chromatin marks in inbred chicken lines
by: Mitra Apratim, et al.
Published: (2012-10-01)

Bivalent Genes Targeting of Glioma Heterogeneity and Plasticity
by: Mariam Markouli, et al.
Published: (2021-01-01)

Assemblage de répétitions de la séquence 601 dans le génome de Saccharomyces cerevisiae pour dicter l'espacement des nucléosomes in vivo
by: Lancrey, Astrid
Published: (2018)

Cold stress induces enhanced chromatin accessibility and bivalent histone modifications H3K4me3 and H3K27me3 of active genes in potato
by: Zixian Zeng, et al.
Published: (2019-06-01)

Primetime for Learning Genes
by: Joyce Keifer
Published: (2017-02-01)

Ethyl pyruvate combats human leukemia cells but spares normal blood cells
by: Birkenmeier, Gerd, et al.
Published: (2016)

ATP-dependent chromatin assembly is functionally distinct from chromatin remodeling
by: Sharon E Torigoe, et al.
Published: (2013-08-01)

Bivalence and the challenge of truth-value gaps
by: Marques, Maria Teresa Matos Ferreira
Published: (2003)

Chromatin regulators: weaving epigenetic nets
by: Hernández-Muñoz Inmaculada
Published: (2010-10-01)

On the location of the linker histones and the linker DNA in the 30 nm fiber of chromatin
by: Leuba, Sanford H.
Published: (2012)

Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement
by: Avinash B Patel, et al.
Published: (2019-12-01)

INFLUENCE OF SMOKING ON THE SALIVARY AND BLOOD CONCENTRATION OF SOME BIVALENT CATIONS IN PATIENTS WITH CHRONIC PERIODONTITIS
by: Al. MANEA, et al.
Published: (2013-03-01)

The role of aTp-dependent chromatin remodeling factors in chromatin assembly in vivo
by: Iu. A. Il’ina, et al.
Published: (2019-03-01)

ATP-Dependent Chromatin Remodeling Factors and Their Roles in Affecting Nucleosome Fiber Composition
by: Alexandra Lusser, et al.
Published: (2011-10-01)

How to build your own island
by: Colum Walsh, et al.
Published: (2014-10-01)

The TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP
by: Huang Q, et al.
Published: (2019-04-01)

Studies on Poly(ADP-ribose) Metabolism and Chromatin Structure
by: Cárdenas-Corona, María E. (María Elena)
Published: (1988)

Chromatin Targeting of HIPK2 Leads to Acetylation-Dependent Chromatin Decondensation
by: Jana Haas, et al.
Published: (2020-09-01)

Basis of specificity for a conserved and promiscuous chromatin remodeling protein
by: Drake A Donovan, et al.
Published: (2021-02-01)

Modifications de l'organisation de la chromatine liées à l’entrée en sénescence et son impact sur la réplication du génome
by: Besnard, Emilie
Published: (2010)

Automatic determination of the dual system width of to a bivalent system
by: Paul Vasiliu
Published: (2018-06-01)

Investigation of the effects of small molecules on chromatin modification
by: Nicolas, Annabelle
Published: (2011)

HiCoP, a simple and robust method for detecting interactions of regulatory regions
by: Yan Zhang, et al.
Published: (2020-07-01)

Reconstitution of Drosophila and human chromatins by wheat germ cell-free co-expression system
by: Kei-ichi Okimune, et al.
Published: (2020-12-01)

The structural role of histone H2A variants in chromatin function
by: Abbott, D. Wade
Published: (2008)

Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature
by: Benjamin I. Laufer, et al.
Published: (2021-03-01)

Switch-Like Roles for Polycomb Proteins from Neurodevelopment to Neurodegeneration
by: Anke Hoffmann, et al.
Published: (2017-12-01)

Développement d'une approche méthodologique basée sur la biotinylation in vivo de protéines de la chromatine - Application à l’étude des interactions entre des domaines chromosomiques et une protéine de l'enveloppe nucléaire dans des cellules individuelles
by: Jurisic, Anamarija
Published: (2016)

Towards the understanding of the function of the histone "tails" with respect to the structure, stability, and function of chromatin
by: Dong, Feng
Published: (2013)

Role des modifications des histones dans le maintien et la lecture de l’empreinte génomique chez la souris.
by: Sanz, Lionel
Published: (2010)

Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups
by: Katherine A. Giles, et al.
Published: (2019-02-01)

Spatial Principles of Chromatin Architecture Associated With Organ-Specific Gene Regulation
by: Douglas J. Chapski, et al.
Published: (2019-01-01)

On the role of inter-nucleosomal interactions and intrinsic nucleosome dynamics in chromatin function
by: Wladyslaw A. Krajewski
Published: (2016-03-01)

Nuclear Pore Proteins in Regulation of Chromatin State
by: Terra M. Kuhn, et al.
Published: (2019-11-01)