Loss of Bace1 in mice does not alter the severity of caerulein induced pancreatitis

Context: Beta-site alpha-amyloid protein cleaving enzyme1 (BACE1) plays a key role in the pathogenesis of Alzheimer’s disease. Additional to its moderate expression in the brain, high levels of BACE1 mRNA were found in the pancreas. Murine Bace1 has been immunohistochemicaly detected at the apical p...

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Main Authors:	Heindl, Mario, Tuennemann, Jan, Sommerer, Ines, Mössner, Joachim, Hoffmeister, Albrecht
Other Authors:	Universitätsklinikum Leipzig, Department für Innere Medizin, Neurologie und Dermatologie
Format:	Article
Language:	English
Published:	Universitätsbibliothek Leipzig 2015
Subjects:	BACE1 Enzym Morbus Alzheimer Gehirn Pankreatitis enzyme Alzheimer’s disease brain pancreatitis ddc:610
Online Access:	http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-170593 http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-170593 http://www.qucosa.de/fileadmin/data/qucosa/documents/17059/OAP-2015-088-Hoffmeister.pone.0125556.pdf

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spelling	ndltd-DRESDEN-oai-qucosa.de-bsz-15-qucosa-1705932015-06-09T03:38:49Z Loss of Bace1 in mice does not alter the severity of caerulein induced pancreatitis Heindl, Mario Tuennemann, Jan Sommerer, Ines Mössner, Joachim Hoffmeister, Albrecht BACE1 Enzym Morbus Alzheimer Gehirn Pankreatitis BACE1 enzyme Alzheimer’s disease brain pancreatitis ddc:610 Context: Beta-site alpha-amyloid protein cleaving enzyme1 (BACE1) plays a key role in the pathogenesis of Alzheimer’s disease. Additional to its moderate expression in the brain, high levels of BACE1 mRNA were found in the pancreas. Murine Bace1 has been immunohistochemicaly detected at the apical pole of acinar cells within the exocrine pancreas of mice and Bace1 activity was observed in pancreatic juice. In vitro experiments revealed enteropeptidase as a putative substrate for Bace1 suggesting a role in acute pancreatitis. Universitätsbibliothek Leipzig Universitätsklinikum Leipzig, Department für Innere Medizin, Neurologie und Dermatologie PLoS, 2015-05-11 doc-type:article application/pdf http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-170593 urn:nbn:de:bsz:15-qucosa-170593 http://www.qucosa.de/fileadmin/data/qucosa/documents/17059/OAP-2015-088-Hoffmeister.pone.0125556.pdf PLoS one 2015, 10(5): e0125556 eng
collection	NDLTD
language	English
format	Article
sources	NDLTD
topic	BACE1 Enzym Morbus Alzheimer Gehirn Pankreatitis BACE1 enzyme Alzheimer’s disease brain pancreatitis ddc:610
spellingShingle	BACE1 Enzym Morbus Alzheimer Gehirn Pankreatitis BACE1 enzyme Alzheimer’s disease brain pancreatitis ddc:610 Heindl, Mario Tuennemann, Jan Sommerer, Ines Mössner, Joachim Hoffmeister, Albrecht Loss of Bace1 in mice does not alter the severity of caerulein induced pancreatitis
description	Context: Beta-site alpha-amyloid protein cleaving enzyme1 (BACE1) plays a key role in the pathogenesis of Alzheimer’s disease. Additional to its moderate expression in the brain, high levels of BACE1 mRNA were found in the pancreas. Murine Bace1 has been immunohistochemicaly detected at the apical pole of acinar cells within the exocrine pancreas of mice and Bace1 activity was observed in pancreatic juice. In vitro experiments revealed enteropeptidase as a putative substrate for Bace1 suggesting a role in acute pancreatitis.
author2	Universitätsklinikum Leipzig, Department für Innere Medizin, Neurologie und Dermatologie
author_facet	Universitätsklinikum Leipzig, Department für Innere Medizin, Neurologie und Dermatologie Heindl, Mario Tuennemann, Jan Sommerer, Ines Mössner, Joachim Hoffmeister, Albrecht
author	Heindl, Mario Tuennemann, Jan Sommerer, Ines Mössner, Joachim Hoffmeister, Albrecht
author_sort	Heindl, Mario
title	Loss of Bace1 in mice does not alter the severity of caerulein induced pancreatitis
title_short	Loss of Bace1 in mice does not alter the severity of caerulein induced pancreatitis
title_full	Loss of Bace1 in mice does not alter the severity of caerulein induced pancreatitis
title_fullStr	Loss of Bace1 in mice does not alter the severity of caerulein induced pancreatitis
title_full_unstemmed	Loss of Bace1 in mice does not alter the severity of caerulein induced pancreatitis
title_sort	loss of bace1 in mice does not alter the severity of caerulein induced pancreatitis
publisher	Universitätsbibliothek Leipzig
publishDate	2015
url	http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-170593 http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-170593 http://www.qucosa.de/fileadmin/data/qucosa/documents/17059/OAP-2015-088-Hoffmeister.pone.0125556.pdf
work_keys_str_mv	AT heindlmario lossofbace1inmicedoesnotaltertheseverityofcaeruleininducedpancreatitis AT tuennemannjan lossofbace1inmicedoesnotaltertheseverityofcaeruleininducedpancreatitis AT sommererines lossofbace1inmicedoesnotaltertheseverityofcaeruleininducedpancreatitis AT mossnerjoachim lossofbace1inmicedoesnotaltertheseverityofcaeruleininducedpancreatitis AT hoffmeisteralbrecht lossofbace1inmicedoesnotaltertheseverityofcaeruleininducedpancreatitis
_version_	1716804961998733312

Loss of Bace1 in mice does not alter the severity of caerulein induced pancreatitis

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