Untersuchungen zur Dynamik und zum Aggregationsmechanismus von alpha-Synuklein in chronischen Toxinmodellen der dopaminergen Primärzellkultur

Untersuchungen zur Dynamik und zum Aggregationsmechanismus von alpha-Synuklein in chronischen Toxinmodellen der dopaminergen Primärzellkultur

Ein Schlüsselbefund der Parkinson-Krankheit auf zellulärer Ebene ist das Auftreten von Protein-Einschlusskörperchen, sogenannten Lewykörperchen. Der Hauptbestandteil dieser Lewykörperchen ist pathologisch aggregiertes, fibrilläres α-Synuklein, ein Protein, welches Einfluss auf präsynaptische Vesikel...

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Bibliographic Details
Main Author:	Oster, Sandra
Other Authors:	Technische Universität Dresden, Medizinische Fakultät Carl Gustav Carus
Format:	Doctoral Thesis
Language:	deu
Published:	Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden 2018
Subjects:	alpha-Synuklein Rotenon Paraquat dopaminerge Primärzellkultur Parkinson Aggregation alpha-synuclein rotenone paraquat dopaminergic primary cell culture Parkinson's disease aggregation ddc:610 rvk:XG 8804
Online Access:	http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-232129 http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-232129 http://www.qucosa.de/fileadmin/data/qucosa/documents/23212/Dissertation_Sandra_Oster_Qucosa_pdfa.pdf

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