Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits

Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits

We report the use of thin film poly(dimethylsiloxane) (PDMS) prints for the arrayed mass production of highly uniform 3-D human HT29 colon carcinoma spheroids. The spheroids have an organotypic density and, as determined by 3-axis imaging, were genuinely spherical. Critically, the array density impa...

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Bibliographic Details
Main Authors:	Hardelauf, Heike, Frimat, Jean-Philippe, Stewart, Joanna D., Schormann, Wiebke, Chiang, Ya-Yu, Lampen, Peter, Franzke, Joachim, Hengstler, Jan G., Cadenas, Cristina, Kunz-Schughart, Leoni A., West, Jonathan
Other Authors:	Royal Society of Chemistry,
Format:	Article
Language:	English
Published:	Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden 2014
Subjects:	Saure Phosphatase Untersuchung Zellkultursystem Hepatozyt Sphäroide Topoisomerase Zellviabilität Wachstum Mikrofabrikation Differenzierung Camptothecin acid-phosphatase assay culture-system hepatocyte spheroids topoisomerase-i cell viability growth microfabrication differentiation camptothecin generation ddc:570 ddc:012 rvk:VA 1120
Online Access:	http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-138739 http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-138739 http://www.qucosa.de/fileadmin/data/qucosa/documents/13873/10.1039c0lc00089b.pdf

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