Increased Aβ Production Leads to Intracellular Accumulation of Aβ in Flotillin-1-Positive Endosomes

Increased Aβ Production Leads to Intracellular Accumulation of Aβ in Flotillin-1-Positive Endosomes

Extracellular accumulation of Aβ in β-amyloid plaques is thought to be associated with the neurodegeneration observed in Alzheimer’s disease (AD) patients, although a lack of correlation with cognitive decline raised doubts on this hypothesis. In different transgenic mouse models Aβ accumulates insi...

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Bibliographic Details
Main Authors: Rajendran, Lawrence, Knobloch, Marlen, Geiger, Kathrin D., Dienel, Stephanie, Nitsch, Roger, Simons, Kai, Konietzko, Uwe
Other Authors: Karger,
Format: Article
Language:English
Published: Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden 2014
Subjects:
Amyloidose
intrazellulär Aβ
multivesikuläres Körper
Alzheimer-Krankheit
Endozytose
transgene Mäuse
Reggie-1
Alzheimer’s disease
Endocytosis
Transgenic mice
Multivesicular bodies
Intracellular Aβ
Amyloid
Reggie
ddc:610
rvk:XA 10000
Online Access:http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136570
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136570
http://www.qucosa.de/fileadmin/data/qucosa/documents/13657/NDD20070042_3164.PDF

Internet

http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136570
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136570
http://www.qucosa.de/fileadmin/data/qucosa/documents/13657/NDD20070042_3164.PDF

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