Analyse reaktiver Toxizitätspotentiale organischer Elektrophile im Chemoassay mit 4-Nitrothiophenol

Analyse reaktiver Toxizitätspotentiale organischer Elektrophile im Chemoassay mit 4-Nitrothiophenol

Zur Bestimmung der toxizitätsrelevanten Thiolreaktivität wurde ein Chemoassay mit dem Modellnukleophil 4-Nitrothiophenol (NBT) entwickelt. Es wurden die Reaktionsgeschwindigkeitskonstanten kNBT für insgesamt 145 Verbindungen aus verschiedenen Stoffklassen bestimmt. Ein Modell zur Berücksichtigung de...

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Bibliographic Details
Main Author:	Hiltrop, Rebecca
Other Authors:	Technische Universität Bergakademie Freiberg, Chemie und Physik
Format:	Doctoral Thesis
Language:	deu
Published:	Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola" 2016
Subjects:	REACH-Verordnung Toxizitätsvorhersage Chemoassay Thiolgruppe Elektrophile Verbindungen Reaktionskinetik Tetrahymena pyriformis REACH legislation toxicity prediction chemoassay thiol group electrophilic compounds reaction kinetics ddc:540 Europäische Union <REACH-Verordnung> Toxizität Prognose Thiophenolderivate
Online Access:	http://nbn-resolving.de/urn:nbn:de:bsz:105-qucosa-194743 http://nbn-resolving.de/urn:nbn:de:bsz:105-qucosa-194743 http://www.qucosa.de/fileadmin/data/qucosa/documents/19474/Dissertation_Hiltrop2.pdf

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