Disruption of the right temporoparietal junction using transcranial magnetic stimulation impairs the control of shared representation of action

• Main Author: Köhlert, Katharina
• Other Authors: Villringer, Arno
• Format: Doctoral Thesis
• Language: English
• Published: Max Planck Institut 2016
• Subjects: info:eu-repo/classification/ddc/610; ddc:610; Transkranielle Magnetstimulation; transcranial magnetic stimulation
• Online Access: http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-203986; https://ul.qucosa.de/id/qucosa%3A14741; https://ul.qucosa.de/api/qucosa%3A14741/attachment/ATT-0/

Previous research and current models have proposed that the right temporoparietal junction (rTPJ) is crucially involved in the control and distinction of shared representations of action. Hitherto, this assumption has mainly been based on neuroimaging work ( (Spengler, von Cramon, & Brass, 2009); (Spengler, von Cramon, & Brass, 2010)) We tested this hypothesis, that the rTPJ is causally involved in managing shared representations by using repetitive transcranial magnetic stimulation in an offline paradigm to disrupt neural activity in this region. Using a simple imitation-inhibition task we showed that stimulation of the rTPJ led to increased reaction times when participants had to control automatic imitation of a perceived hand movement, as they had to concurrently plan and execute an opposite movement. Our study provides the first empirical evidence that the rTPJ is necessary for managing and navigating within a shared representational system. These results may also have important implications for future theorizing about the role of the TPJ region in controlling shared representations also in other domains, such as somatosensation or emotional experiences.:1 Bibliografische Beschreibung 2 Introduction 2.1 Imitation 2.1.1 Automatic imitation and mirroring 2.1.2 Control of automatic imitation 2.2 Functional Neuroanatomy 2.2.1 Temporo-parietal junction (TPJ) 2.2.2 Function of the right TPJ 2.3 Transcranial magnetic stimulation (TMS) 2.3.1 History 2.3.2 Physical Basis of TMS 2.3.3 TMS stimulatore 2.3.4 rTMS 2.3.5 Medical Use 3 Own Study: Aims and research questions 3.1 Research Questions 4 Materials and Methods 4.1 Participants 4.2 General procedure 4.3 Imitation-Inhibition task 4.4 TMS- protocol 4.5 Data analysis 5 Results 6 Discussion 7 Conclusion 8 Literatur directory 9 Figures and Table 10 Curriculum Vitae 12 Erklärung über die eigenständige Abfassung der Arbeit