Tumour-selective apoptosis : identification of NMHCIIa as novel death receptor interactor regulating the response to TRAIL

Tumour-selective apoptosis : identification of NMHCIIa as novel death receptor interactor regulating the response to TRAIL

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The cytokine TRAIL is a promising cancer therapeutic candidate as it induces apoptosis selectively in transformed cells. TRAIL-induced clustering of its receptors (DR) is essential for the DISC complex formation, which induces cell death. The mechanism for TRAIL's tumour selective effect is lar...

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Bibliographic Details
Main Author: Schulz, Cathrin
Language:English
Published: Université de Strasbourg 2012
Subjects:
[SDV:SA] Life Sciences/Agricultural sciences
[SDV:SA] Sciences du Vivant/Sciences agricoles
[SDV:MHEP] Life Sciences/Human health and pathology
[SDV:MHEP] Sciences du Vivant/Médecine humaine et pathologie
TRAIL
DISC
Normal cells
Apoptosis
Tumour-selective
Cytoskeleton
Non-muscle myosin heavy chain IIa
NMHCIIa
Online Access:http://tel.archives-ouvertes.fr/tel-01069133
http://tel.archives-ouvertes.fr/docs/01/06/91/33/PDF/Schulz_Cathrin_2012_ED414.pdf

Internet

http://tel.archives-ouvertes.fr/tel-01069133
http://tel.archives-ouvertes.fr/docs/01/06/91/33/PDF/Schulz_Cathrin_2012_ED414.pdf

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