Engineering of Lactic Acid Bacteria strains modulating immune response for vaccination and delivery of therapeutics
The use of Lactic Acid Bacteria (LAB), such as Lactococcus lactis (LL), as DNA delivery vehicles represents an interesting strategy as they are regarded as safe. Wild type (wt) LL or recombinant invasive LL, were able to trigger DNA expression by epithelial cells both in vitro and in vivo. However,...
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| Language: | English |
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Université Paris Sud - Paris XI
2013
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| Online Access: | http://tel.archives-ouvertes.fr/tel-00981946 http://tel.archives-ouvertes.fr/docs/00/98/19/46/PDF/VD2_AZEVEDO_MARCELA_25102013.pdf http://tel.archives-ouvertes.fr/docs/00/98/19/46/ANNEX/VD2_AZEVEDO_MARCELA_25102013_Synthese_en_francais_Annexes.pdf |