Complementarité des protéines de detoxication et trafic intracellulaire

Complementarité des protéines de detoxication et trafic intracellulaire

La coopération fonctionnelle entre le cytochrome P450 3A (CYP3A) et la P-glycoprotéine (P-gp) décrite dans la littérature est un facteur déterminant contribuant à la variabilité de la biodisponibilité de la plupart des médicaments administrés per os. Le CYP3A et la P-gp sont des protéines membranair...

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Bibliographic Details
Main Author:	Cavelier, Adeline
Language:	FRE
Published:	Université René Descartes - Paris V 2007
Subjects:	[SDV] Life Sciences Cytochrome P450 3A P-glycoprotéine Microscopie à épifluorescence Coupes de foie Hépatocytes Fibroblastes D/ADX Résorufine Vérapamil bodipy
Online Access:	http://tel.archives-ouvertes.fr/tel-00553511 http://tel.archives-ouvertes.fr/docs/00/55/35/11/PDF/These_Cavellier_Adeline_2007_CEA-iBiTecs.pdf

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