Analyse de l'activation du facteur oedémateux de Bacillus anthracis par la calmoduline, en vue de la recherche d'inhibiteurs

Analyse de l'activation du facteur oedémateux de Bacillus anthracis par la calmoduline, en vue de la recherche d'inhibiteurs

La virulence de la bactérie Gram+ Bacillus anthracis, responsable de la maladie du charbon, est due à la présence d'une capsule et deux toxines. Chaque toxine résulte de l'assemblage de l'antigène protecteur (PA) avec l'un des deux facteurs, létal (LF) ou oedémateux (EF), dans le...

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Bibliographic Details
Main Author:	Laine, Elodie
Language:	FRE
Published:	Université Pierre et Marie Curie - Paris VI 2009
Subjects:	[SDV:SP:MED] Life Sciences/Pharmaceutical sciences/Medication Bacillus anthracis facteur oedémateux calmoduline calcium dynamique moléculaire détermination de chemin de réaction recherche rationnelle d'inhibiteurs allostérie
Online Access:	http://tel.archives-ouvertes.fr/tel-00483602 http://tel.archives-ouvertes.fr/docs/00/48/36/02/PDF/2009-Elodie_Laine.pdf http://tel.archives-ouvertes.fr/docs/00/48/36/02/ANNEX/2009-Elodie_Laine.pptx

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